US9242973, RP11a

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: US9242973, RP11a
• 化学式: C₁₆H₁₉BrN₂O₃
• 分子量: 367.24
• InChiKey: PCABGJMPWSJFMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  66.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• CHROMANE COMPOUNDS
  申请人：CoMentis, Inc.

  公开号：US20150225386A1

  公开（公告）日：2015-08-13

  The present invention provides a hydrate of N-[(4S)-2-amino-2′,2′-dimethyldispiro[1,3-oxazole-4,4′-chromene-3′,3″-oxetan]-6′-yl]-5-chloropyridine-2-carboxamide which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing or treating diseases or conditions associated with and/or mediated by β-secretase activity, hydrolysis of a β-secretase site of a β-amyloid precursor protein, and/or β-amyloid protein accumulation, including a pharmaceutical composition for preventing or treating diseases including, but not limited to, Glaucoma, MCI (Mild cognitive impairment) or Alzheimer's disease, especially, Alzheimer's disease.

  本发明提供了一种N-[(4S)-2-氨基-2′,2′-二甲基二螺并[1,3-噁唑-4,4′-色烯-3′,3″-氧杂环辛]-6′-基]-5-氯吡啶-2-羧酰胺的水合物，其作为药物组成物的活性成分非常有用，特别是用于预防或治疗与/或介导β-分泌酶活性、β-淀粉样前体蛋白的β-分泌酶位点的水解以及/或β-淀粉样蛋白的积累有关的疾病或症状的药物组成物，包括预防或治疗包括但不限于青光眼、轻度认知障碍或阿尔茨海默病等疾病的药物组成物，特别是阿尔茨海默病。
• US9242973B2
  申请人：——

  公开号：US9242973B2

  公开（公告）日：2016-01-26
• [EN] CHROMANE COMPOUNDS<br/>[FR] COMPOSÉS DE CHROMANE
  申请人：ASTELLAS PHARMA INC

  公开号：WO2013181202A2

  公开（公告）日：2013-12-05

  The present invention provides a compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing or treating diseases or conditions associated with and/or mediated by β-secretase activity, hydrolysis of a β-secretase site of a β -amyloid precursor protein, and/or β -amyloid protein accumulation, including a pharmaceutical composition for preventing or treating diseases including, but not limited to, Glaucoma, MCI (Mild cognitive impairment) or Alzheimer's disease, especially, Alzheimer's disease.