(1R,17S,19R)-6,19-dimethyl-17-[(3,4,5-trimethylphenyl)methylperoxy]-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 柯楠因类生物碱
• 英文名称: (1R,17S,19R)-6,19-dimethyl-17-[(3,4,5-trimethylphenyl)methylperoxy]-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban
• 化学式: C₃₁H₄₀N₂O₂
• 分子量: 472.7
• InChiKey: KLIIZFAGSRCGSN-BFDMGWDOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  35
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  37.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• IDENTIFICATION OF SMALL MOLECULES THAT FACILITATE THERAPEUTIC EXON SKIPPING
  申请人：Nelson Stanley F.

  公开号：US20140080896A1

  公开（公告）日：2014-03-20

  This invention relates, e.g., to a method for enhancing exon skipping in a pre-mRNA of interest, comprising contacting the pre-mRNA with an effective amount of a small molecule selected from the compounds shown in Table 1, or a pharmaceutically acceptable salt, hydrate, solvate, or isomer thereof, and, optionally, with an antisense oligonucleotide that is specific for a splicing sequence in the pre-mRNA Methods for treating Duchenne muscular dystrophy (DMD) are disclosed.