4-imino-2-(1H-1,2,4-triazol-5-ylsulfanyl)naphthalen-1-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-imino-2-(1H-1,2,4-triazol-5-ylsulfanyl)naphthalen-1-one
• 化学式: C₁₂H₈N₄OS
• 分子量: 256.29
• InChiKey: GEIYPPMECQOQNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Methods for inhibiting fascin
  申请人：Novita Pharmaceuticals, Inc.

  公开号：US10208043B2

  公开（公告）日：2019-02-19

  Provided are compositions and methods for treating a condition or disorder mediated by fascin activity in a subject in need thereof which method comprises administering to the subject a therapeutically effective amount of at least one compound of any one of Formula I-a to I-n, II, II-a, II-b or III or a pharmaceutically acceptable salt thereof.

  提供了用于治疗有需要的受试者中由 fascin 活性介导的病症或紊乱的组合物和方法，该方法包括向受试者施用治疗有效量的至少一种式 I-a 至 I-n、II、II-a、II-b 或 III 中任何一种的化合物或其药学上可接受的盐。
• METHODS FOR INHIBITING FASCIN
  申请人：Cornell University

  公开号：US20140080843A1

  公开（公告）日：2014-03-20

  Provided are compositions and methods for treating a condition or disorder mediated by fascin activity in a subject in need thereof which method comprises administering to the subject a therapeutically effective amount of at least one compound of any one of Formula I-a to I-n, II, II-a, II-b or III or a pharmaceutically acceptable salt thereof.
• [EN] METHODS FOR INHIBITING FASCIN<br/>[FR] MÉTHODES D'INHIBITION DE LA FASCINE
  申请人：UNIV CORNELL

  公开号：WO2014031732A2

  公开（公告）日：2014-02-27

  Provided are compositions and methods for treating a condition or disorder mediated by fascin activity in a subject in need thereof which method comprises administering to the subject a therapeutically effective amount of at least one compound of any one of Formula I-a to I-n, II, II-a, II-b or III or a pharmaceutically acceptable salt thereof.