[2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] phosphono hydrogen phosphate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: [2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] phosphono hydrogen phosphate
• 化学式: C₁₈H₂₂O₁₁P₂
• 分子量: 476.3
• InChiKey: CEUSIHLYAQUPOM-WAYWQWQTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  150
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• Naturally-occurring CpG oligonucleotide compositions and therapeutic applications thereof
  申请人：LABYRINTH HOLDINGS, LLC

  公开号：US10688177B2

  公开（公告）日：2020-06-23

  The present invention relates to combination therapies for the treatment of a variety of disorders in mammals, including hepatic disorders and cancer. The combination of agents includes naturally-occurring (versus synthetic) oligonucleotides, particularly immunostimulatory oligodeoxynucleotides such as CpG ODNs, obtained from a natural source and one or more extracts from a Gram positive bacteria, such as Lactobacillus spp.

  本发明涉及治疗哺乳动物各种疾病（包括肝脏疾病和癌症）的组合疗法。药物组合包括从天然来源获得的天然存在的（相对于合成的）寡核苷酸，特别是免疫刺激性寡核苷酸，如 CpG ODNs，以及一种或多种革兰氏阳性细菌（如乳酸杆菌属）的提取物。
• Naturally-Occurring CpG Oligonucleotide Compositions and Therapeutic Applications Thereof
  申请人：McKenna Elizabeth

  公开号：US20140086849A1

  公开（公告）日：2014-03-27

  The present invention relates to combination therapies for the treatment of a variety of disorders in mammals, including hepatic disorders and cancer. The combination of agents includes naturally-occurring (versus synthetic) oligonucleotides, particularly immunostimulatory oligodeoxynucleotides such as CpG ODNs, obtained from a natural source and one or more extracts from a Gram positive bacteria, such as Lactobacillus spp.
• US9931398B2
  申请人：——

  公开号：US9931398B2

  公开（公告）日：2018-04-03