ethyl N-(3,4-dihydroxy-5-naphthalen-1-ylfuran-2-yl)carbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: ethyl N-(3,4-dihydroxy-5-naphthalen-1-ylfuran-2-yl)carbamate
• 化学式: C₁₇H₁₅NO₅
• 分子量: 313.3
• InChiKey: KOYFSYDNHCNBBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  91.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER
  申请人：Rhode Island Hospital

  公开号：EP2897607A2

  公开（公告）日：2015-07-29
• [EN] INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER<br/>[FR] INHIBITEURS DE BÊTA-HYDROLASE POUR LE TRAITEMENT DU CANCER
  申请人：RHODE ISLAND HOSPITAL

  公开号：WO2014047519A2

  公开（公告）日：2014-03-27

  The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2- heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.