5-(Acetylsulfamoyl)furan-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: 5-(Acetylsulfamoyl)furan-2-carboxylic acid
• 英文别名: 5-(acetylsulfamoyl)furan-2-carboxylic acid
• 化学式: C₇H₇NO₆S
• 分子量: 233.2
• InChiKey: RJUDQOSZKPBFDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  122
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS
  申请人：VANDERBILT UNIVERSITY

  公开号：US20150336925A1

  公开（公告）日：2015-11-26

  The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.

  本发明提供了一种抑制抗凋亡Bcl-2家族成员髓系细胞白血病-1（Mcl-1）蛋白活性的化合物。本发明还提供了制药组合物以及使用化合物治疗因Mcl-1蛋白过度表达或失调而表现出的疾病和症状（例如癌症）的方法。
• [EN] AROMATIC SPIRO RING AMIDE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION<br/>[FR] DÉRIVÉS D'AMIDE DE NOYAU SPIRO AROMATIQUE POUR LE TRAITEMENT ET LA PROPHYLAXIE D'UNE INFECTION PAR LE VIRUS DE L'HÉPATITE B
  申请人：HOFFMANN LA ROCHE

  公开号：WO2022112207A1

  公开（公告）日：2022-06-02

  The present invention provides novel compounds having the general formula wherein A1to A4, X1, Rx, Ry, Cy, L and R1are as described herein, compositions including the compounds and methods of using the compounds.

  本发明提供了具有一般式的新化合物，其中A1到A4，X1，Rx，Ry，Cy，L和R1如本文所述，包括该化合物的组合物和使用该化合物的方法。
• [EN] N-[(1,3-BENZOXAZOL-2-YL)-HETEROCYCLE]AMIDE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION<br/>[FR] DÉRIVÉS DE N-[(1,3-BENZOXAZOL-2-YL)-HÉTÉROCYCLE]AMIDE POUR LE TRAITEMENT ET LA PROPHYLAXIE D'UNE INFECTION PAR LE VIRUS DE L'HÉPATITE B
  申请人：HOFFMANN LA ROCHE

  公开号：WO2022106680A1

  公开（公告）日：2022-05-27

  The present invention provides novel compounds having the general formula: (Formula I) wherein A1to A4, X, Cy and R1are as described herein, compositions including the compounds and methods of using the compounds as HBsAg inhibitors for the treatment of HBV infection.

  本发明提供了具有一般式为(Formula I)的新化合物，其中A1至A4，X，Cy和R1如本文所述，包括该化合物的组合物和使用该化合物作为HBsAg抑制剂治疗HBV感染的方法。
• [EN] SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS<br/>[FR] INHIBITEURS DE LA MCL-1 À BASE DE BENZOFURANE, DE BENZOTHIOPHÈNE ET D'INDOLE SUBSTITUÉS
  申请人：UNIV VANDERBILT

  公开号：WO2014047427A2

  公开（公告）日：2014-03-27

  The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.