6-Bromo-1-tert-butylindazole;5-bromoindazole-1,3-dicarboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 6-Bromo-1-tert-butylindazole;5-bromoindazole-1,3-dicarboxylic acid
• 英文别名: 6-bromo-1-tert-butylindazole;5-bromoindazole-1,3-dicarboxylic acid
• 化学式: C20H18Br2N4O4
• 分子量: 538.2
• InChiKey: DLOPJRGQCJJFRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.58
• 重原子数：
  30
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• GDF-8 INHIBITORS
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：EP2903978A1

  公开（公告）日：2015-08-12
• [EN] GDF-8 INHIBITORS<br/>[FR] INHIBITEURS DE GDF-8
  申请人：RIGEL PHARMACEUTICALS INC

  公开号：WO2014055955A1

  公开（公告）日：2014-04-10

  Described are GCF-8 inhibitors of the formula (I), and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R5, R6, X and Z are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for inhibiting GDF-8 in a cell and methods for treating a patient suffering from a disease or disorder, wherein the patient would therapeutically benefit from an increase in mass or strength of muscle tissue.