[1-[[6-Methoxy-4-[5-(methylcarbamoyl)naphthalen-2-yl]oxyquinolin-7-yl]oxymethyl]cyclopropyl] carbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: [1-[[6-Methoxy-4-[5-(methylcarbamoyl)naphthalen-2-yl]oxyquinolin-7-yl]oxymethyl]cyclopropyl] carbamate
• 英文别名: [1-[[6-methoxy-4-[5-(methylcarbamoyl)naphthalen-2-yl]oxyquinolin-7-yl]oxymethyl]cyclopropyl] carbamate
• 化学式: C₂₇H₂₅N₃O₆
• 分子量: 487.5
• InChiKey: UYYRDZCDSMVJCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  122
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• PROCESS FOR THE PREPARATION OF 6-(7-((1-AMINOCYCLOPROPYL)METHOXY)-6-METHOXYQUINOLIN-4-YLOXY)-N-METHYL-1-NAPHTHAMIDE AND SYNTHETIC INTERMEDIATES THEREOF
  申请人：EOS ETHICAL ONCOLOGY SCIENCE S.p.A. in abbreviated form EOS S.p.A.

  公开号：US20140114075A1

  公开（公告）日：2014-04-24

  A process for the preparation in high yields and purity of the compound 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously described, in particular it avoids the use of acyl azide intermediates and their Curtius rearrangement. Novel intermediates useful for the preparation of compound (I) are also described.

  本发明提供了一种制备式（I）化合物及其药用可接受盐的高收率和高纯度的方法。该方法相较于之前的方法具有多种优势，特别是避免了使用酰基叠氮中间体及其Curtius重排反应。同时，本发明还提供了用于制备式（I）化合物的新型中间体。
• Process for the Preparation of 6-(7-((1-Aminocyclopropyl)Methoxy)-6-Methoxyquinolin-4-Yloxy)-N-Methyl-1-Naphthamide and Synthetic Intermediates Thereof
  申请人：Clovis Oncology Italy S.r.l.

  公开号：US20150191429A1

  公开（公告）日：2015-07-09

  A process for the preparation in high yields and purity of the compound 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously described, in particular it avoids the use of acyl azide intermediates and their Curtius rearrangement. Novel intermediates useful for the preparation of compound (I) are also described.

  本发明提供了一种制备式(I)化合物及其药学上可接受的盐的高产率和高纯度的方法。该方法与先前描述的方法相比具有各种优点，特别是它避免了使用酰基叠氮中间体及其Curtius重排。还描述了用于制备化合物(I)的新型中间体。
• US9012645B2
  申请人：——

  公开号：US9012645B2

  公开（公告）日：2015-04-21
• US9340508B2
  申请人：——

  公开号：US9340508B2

  公开（公告）日：2016-05-17