[2-[2-[17-[2-[1-[2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-6-yl]-4-methylpyrrolidin-1-yl]-2-oxo-1-phenylethyl]-methylcarbamic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: [2-[2-[17-[2-[1-[2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-6-yl]-4-methylpyrrolidin-1-yl]-2-oxo-1-phenylethyl]-methylcarbamic acid
• 化学式: C₄₇H₅₀N₈O₇
• 分子量: 838.9
• InChiKey: CMIBAZLXBMWSLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  62
• 可旋转键数：
  10
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  186
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• ANTIVIRAL COMPOUNDS
  申请人：Bacon Elizabeth M.

  公开号：US20140112885A1

  公开（公告）日：2014-04-24

  The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本公开涉及抗病毒化合物、含有此类化合物的组合物、包括给予此类化合物的治疗方法，以及用于制备此类化合物的工艺和中间体。
• CONDENSED IMIDAZOLYLIMIDAZOLES AS ANTIVIRAL COMPOUNDS
  申请人：Gilead Pharmasset LLC

  公开号：EP3431477A1

  公开（公告）日：2019-01-23

  The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本公开涉及抗病毒化合物、含有此类化合物的组合物、包括施用此类化合物的治疗方法，以及用于制备此类化合物的工艺和中间体。
• US8921341B2
  申请人：——

  公开号：US8921341B2

  公开（公告）日：2014-12-30