N-(3-(1H-1,2,4-triazol-3-ylthio)-4-hydroxynaphthalen-1-yl)-4-ethyl-benzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(3-(1H-1,2,4-triazol-3-ylthio)-4-hydroxynaphthalen-1-yl)-4-ethyl-benzenesulfonamide
• 英文别名: 4-ethyl-N-[4-hydroxy-3-(1H-1,2,4-triazol-5-ylsulfanyl)naphthalen-1-yl]benzenesulfonamide
• 化学式: C₂₀H₁₈N₄O₃S₂
• 分子量: 426.5
• InChiKey: QDGHREVQMWQVBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  142
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Methods for inhibiting fascin
  申请人：Novita Pharmaceuticals, Inc.

  公开号：US10208043B2

  公开（公告）日：2019-02-19

  Provided are compositions and methods for treating a condition or disorder mediated by fascin activity in a subject in need thereof which method comprises administering to the subject a therapeutically effective amount of at least one compound of any one of Formula I-a to I-n, II, II-a, II-b or III or a pharmaceutically acceptable salt thereof.

  提供了用于治疗有需要的受试者中由 fascin 活性介导的病症或紊乱的组合物和方法，该方法包括向受试者施用治疗有效量的至少一种式 I-a 至 I-n、II、II-a、II-b 或 III 中任何一种的化合物或其药学上可接受的盐。
• METHODS FOR INHIBITING FASCIN
  申请人：Cornell University

  公开号：EP2888010A2

  公开（公告）日：2015-07-01
• FASCIN BINDING COMPOUNDS FOR SPINOGENESIS
  申请人：SPINOGENIX, INC.

  公开号：US20210330646A1

  公开（公告）日：2021-10-28

  In some embodiments, a method of promoting spinogenesis in a patient is provided, comprising administering to a patient in need thereof a therapeutically effective amount of a compound which binds to fascin at least at binding site 2 or binding site 3.
• [EN] METHODS FOR INHIBITING FASCIN<br/>[FR] MÉTHODES D'INHIBITION DE LA FASCINE
  申请人：UNIV CORNELL

  公开号：WO2014031732A2

  公开（公告）日：2014-02-27

  Provided are compositions and methods for treating a condition or disorder mediated by fascin activity in a subject in need thereof which method comprises administering to the subject a therapeutically effective amount of at least one compound of any one of Formula I-a to I-n, II, II-a, II-b or III or a pharmaceutically acceptable salt thereof.