4-[(Z)-1-[4-[2-[methyl(pyrrolidin-1-ylmethyl)amino]ethoxy]phenyl]-2-phenylbut-1-enyl]phenol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 4-[(Z)-1-[4-[2-[methyl(pyrrolidin-1-ylmethyl)amino]ethoxy]phenyl]-2-phenylbut-1-enyl]phenol
• 化学式: C₃₀H₃₆N₂O₂
• 分子量: 456.6
• InChiKey: NJQAVSYDKPLSAQ-FLWNBWAVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  35.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• TRANS-CLOMIPHENE FOR USE IN CANCER THERAPY
  申请人：Repros Therapeutics Inc.

  公开号：EP2914294A1

  公开（公告）日：2015-09-09
• Trans-Clomiphene for Use in Cancer Therapy
  申请人：REPROS THERAPEUTICS INC.

  公开号：US20150283099A1

  公开（公告）日：2015-10-08

  The present invention relates to the administration of compositions comprising an antiestrogen, preferably a selective estrogen receptor modulator (SERM) such as trans-clomiphene, for treating cancer and associated diseases. The invention is also directed to methods for reducing IGF-1 levels in a subject in need thereof by administering a composition comprising an antiestrogen, preferably a SERM such as trans-clomiphene.
• US9687458B2
  申请人：——

  公开号：US9687458B2

  公开（公告）日：2017-06-27
• [EN] TRANS-CLOMIPHENE FOR USE IN CANCER THERAPY<br/>[FR] TRANS-CLOMIPHÈNE POUR UNE UTILISATION EN CANCÉROTHÉRAPIE
  申请人：REPROS THERAPEUTICS INC

  公开号：WO2014070523A1

  公开（公告）日：2014-05-08

  The present invention relates to the administration of compositions comprising an antiestrogen, preferably a selective estrogen receptor modulator (SERM) such as trans-clomiphene, for treating cancer and associated diseases. The invention is also directed to methods for reducing IGF-1 levels in a subject in need thereof by administering a composition comprising an antiestrogen, preferably a SERM such as trans-clomiphene.