2-Fluoroethyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: 2-Fluoroethyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate
• 英文别名: 2-fluoroethyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate
• 化学式: C₈H₁₁FO₅
• 分子量: 206.17
• InChiKey: IVVBLMPQGAWULN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• BIODEGRADABLE BLOCK POLYMERS FOR DRUG DELIVERY, AND METHODS RELATED THERETO
  申请人：Hedrick James

  公开号：US20110152167A1

  公开（公告）日：2011-06-23

  A biodegradable block copolymer is disclosed, comprising a hydrophilic block derived from a polyether alcohol; and a hydrophobic block comprising a first repeat unit derived by ring opening polymerization of a first cyclic carbonyl monomer initiated by the polyether alcohol, the first repeat unit comprising a side chain moiety comprising a functional group selected from the group consisting of urea groups, a carboxylic acid groups, and mixtures thereof. No side chain of the hydrophobic block comprises a covalently bound biologically active material. The block copolymer self-assembles in water forming micelles suitable for sequestering a biologically active material by a non-covalent interaction, and the block copolymer is 60% biodegraded within 180 days in accordance with ASTM D6400.

  一种可生物降解的嵌段共聚物被披露，包括源自聚醚醇的亲水性块；和包括由聚醚醇引发的第一环状羰基单体的环开聚合得到的疏水性块，该第一重复单元包括一个侧链基团，该侧链基团包括从尿素基团、羧酸基团或它们的混合物中选择的功能基团。疏水性块的任何侧链均不包括共价结合的生物活性物质。该嵌段共聚物在水中自组装形成适合通过非共价相互作用固定生物活性物质的胶束，并且根据ASTM D6400标准，该嵌段共聚物在180天内生物降解60%。
• CATIONIC POLYMERS FOR ANTIMICROBIAL APPLICATIONS AND DELIVERY OF BIOACTIVE MATERIALS
  申请人：Coady Daniel Joseph

  公开号：US20120251608A1

  公开（公告）日：2012-10-04

  A cationic star polymer is disclosed of the general formula (1): I′P′] w′ (1), wherein w′ is a positive number greater than or equal to 3, I′ is a dendritic polyester core covalently linked to w′ independent peripheral linear cationic polymer chains P′. Each of the chains P′ comprises a cationic repeat unit comprising i) a backbone functional group selected from the group consisting of aliphatic carbonates, aliphatic esters, aliphatic carbamates, aliphatic ureas, aliphatic thiocarbamates, aliphatic dithiocarbonates, and combinations thereof, and ii) a side chain comprising a quaternary amine group. The quaternary amine group comprises a divalent methylene group directly covalently linked to i) a positive charged nitrogen and ii) an aromatic ring.

  公开了一种阳离子星形聚合物，其一般式为（1）：I′P′]w′（1），其中w′是大于或等于3的正数，I′是一个树枝状聚酯核心，与w′个独立的外周线性阳离子聚合物链P′共价连接。每个链P′包括一个阳离子重复单元，包括i）从群组中选择的骨架功能基，该群组包括脂肪族碳酸酯，脂肪族酯，脂肪族氨基甲酸酯，脂肪族脲，脂肪族硫脲酸酯，脂肪族二硫代碳酸酯及其组合物，以及ii）包括季铵基团的侧链。季铵基团包括一个二价亚甲基基团，直接共价连接到i）一个正电荷氮和ii）一个芳香环。
• STAR POLYMER NANOSHELLS AND METHODS OF PREPARATION THEREOF
  申请人：Lee Victor Yee-Way

  公开号：US20120237447A1

  公开（公告）日：2012-09-20

  A nanoshell is disclosed, comprising a star polymer occlusion complex comprising i) an amphiphilic unimolecular star polymer having a crosslinked core covalently linked to 6 or more independent polymer arms, and ii) a cargo material occluded in the star polymer; and a shell comprising an inorganic material in contact with a peripheral surface of the star polymer occlusion complex.
• BIODEGRADABLE POLYMERS, COMPLEXES THEREOF FOR GENE THERAPEUTICS AND DRUG DELIVERY, AND METHODS RELATED THERETO
  申请人：INTERNATIONAL BUSINESS MACHINES CORPORATION

  公开号：US20170114182A1

  公开（公告）日：2017-04-27

  A biodegradable cationic polymer is disclosed, comprising first repeat units derived from a first cyclic carbonyl monomer by ring-opening polymerization, wherein more than 0% of the first repeat units comprise a side chain moiety comprising a quaternary amine group; a subunit derived from a monomeric diol initiator for the ring-opening polymerization; and an optional endcap group. The biodegradable cationic polymers have low cytotoxicity and form complexes with biologically active materials useful in gene therapeutics and drug delivery.
• US8470891B2
  申请人：——

  公开号：US8470891B2

  公开（公告）日：2013-06-25