2-[(1E,3E,5E,7E)-7-(1,1-dimethyl-3H-benzo[e]indol-2-ylidene)hepta-1,3,5-trienyl]-1,1-dimethylbenzo[e]indole

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-[(1E,3E,5E,7E)-7-(1,1-dimethyl-3H-benzo[e]indol-2-ylidene)hepta-1,3,5-trienyl]-1,1-dimethylbenzo[e]indole
• 化学式: C₃₅H₃₂N₂
• 分子量: 480.6
• InChiKey: VIRGRCAVDFVAII-SSKKYROOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.4
• 重原子数：
  37
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• COMPOSITION HAVING DYE AND CONJUGATE OF POLYETHYLENEGLYCOL AND ADDITIVE AND CONTRAST AGENT FOR PHOTOACOUSTIC IMAGING HAVING THE SAME
  申请人：Canon Kabushiki Kaisha

  公开号：EP2992904A1

  公开（公告）日：2016-03-09

  The present invention provides contrast agents for photoacoustic imaging which exhibit high degrees of accumulation in tumor and low degrees of retention in the blood and can be administered into the blood. The contrast agents for photoacoustic imaging include a conjugate of a dye and a polyethyleneglycol represented by Formula (1), (5), (6), or (7) and an additive represented by Formula (301).

  本发明提供了用于光声成像的造影剂，这种造影剂在肿瘤中的蓄积程度高，而在血液中的滞留程度低，并可注入血液。用于光声成像的造影剂包括由式（1）、（5）、（6）或（7）表示的染料和聚乙二醇的共轭物以及由式（301）表示的添加剂。
• NEAR-INFRARED DYE-BOUND TRANSFERRIN, AND CONTRAST AGENT FOR PHOTOACOUSTIC IMAGING, INCLUDING THE NEAR-INFRARED DYE-BOUND TRANSFERRIN
  申请人：Canon Kabushiki Kaisha

  公开号：EP3072530A1

  公开（公告）日：2016-09-28

  A novel near-infrared dye-bound transferrin exhibiting a high absorption coefficient in the near-infrared wavelength region, a high tumor accumulation property, a high tumor/blood ratio and a high imaging contrast, and a contrast agent for photoacoustic imaging, including the same are provided. A compound is provided in which transferrin and an organic dye having a specified structure that absorbs light in the near-infrared wavelength region are covalently bound.

  本发明提供了一种新型近红外染料结合转铁蛋白，该转铁蛋白在近红外波长区域具有高吸收系数、高肿瘤蓄积特性、高肿瘤/血液比值和高成像对比度，以及包括该转铁蛋白在内的光声成像对比剂。提供了一种化合物，其中转铁蛋白和具有特定结构的有机染料共价结合，该染料在近红外波长区域吸收光。
• METHOD OF MEASURING PROPULSION IN LYMPHATIC STRUCTURES
  申请人：BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

  公开号：US20140121514A1

  公开（公告）日：2014-05-01

  Novel methods and imaging agents for functional imaging of lymph structures are disclosed herein. Embodiments of the methods utilize highly sensitive optical imaging and fluorescent spectroscopy techniques to track or monitor packets of organic dye flowing in one or more lymphatic structures. The packets of organic dye may be tracked to provide quantitative information regarding lymph propulsion and function. In particular, lymph flow velocity and pulse frequency may be determined using the disclosed methods.
• FLUORESCENT PHOSPHOLIPID ETHER COMPOUNDS, COMPOSITIONS, AND METHODS OF USE
  申请人：Cellectar, Inc.

  公开号：US20150044142A1

  公开（公告）日：2015-02-12

  The invention generally relates to novel fluorescent phospholipid compounds, compositions comprising these compounds, and diagnostic methods utilizing these compounds. A preferred compound of the present invention has the following structural formula:
• CONTRAST AGENT FOR PHOTOACOUSTIC IMAGING
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20150290345A1

  公开（公告）日：2015-10-15

  There is provided a contrast agent for photoacoustic imaging, the contrast agent exhibiting high tumor accumulation and high photoacoustic signal intensity even when time has passed since administration. A contrast agent for photoacoustic imaging comprises a complex including albumin covalently bound to an organic dye that absorbs light in the near-infrared wavelength region.