1,4-Dichloro-6-methylnaphthalene

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1,4-Dichloro-6-methylnaphthalene
• 英文别名: 1,4-dichloro-6-methylnaphthalene
• 化学式: C₁₁H₈Cl₂
• 分子量: 211.08
• InChiKey: XGEHWSPBQPYBIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• SUBSTITUTED SULFONAMIDES USEFUL AS ANTIAPOPTOTIC BCL INHIBITORS
  申请人：Borzilleri Robert M.

  公开号：US20140135318A1

  公开（公告）日：2014-05-15

  Disclosed are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: W and Q and G are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bcl-2 family antiapoptotic proteins for the treatment of cancer; and pharmaceutical compositions comprising such compounds.

  本发明涉及式（I）的化合物或其药学上可接受的盐，其中：W、Q和G的定义如下。还公开了使用这些化合物作为Bcl-2家族抗凋亡蛋白的抑制剂用于治疗癌症的方法；以及包含这些化合物的药物组合物。
• CONTRAST AGENTS BASED ON LONG-LIVED NUCLEAR SINGLET STATES AND RELATED METHODS
  申请人：Duke University

  公开号：US20150064113A1

  公开（公告）日：2015-03-05

  Methods are described for preparing magnetic resonance imaging (MRI) and/or magnetic resonance spectroscopy contrast agents where the contrast agents are prepared from precursor molecules having at least four non-zero-spin nuclei that form two pairs of chemically equivalent or effectively equivalent nuclei, e.g., diphenylacetylene or diethyl oxalate. The precursor molecule is hyperpolarized and a sequence of one or more radiofrequency pulses is applied to transfer spin state population between the first and second pair of nuclei, thereby providing a non-equilibrium single state nuclear spin population. To detect the contrast agent, another sequence of one or more radiofrequency pulses is applied to transfer singlet order to polarization. No transformation of the molecular structure of the contrast agent is necessary for detection. Also described are methods of imaging targets using the contrast agents.

  本文描述了制备磁共振成像（MRI）和/或磁共振波谱学对比剂的方法，其中对比剂是由至少四个非零自旋核形成的前体分子制备而成，这些核形成两对化学等价或有效等价的核，例如二苯乙炔或草酸二乙酯。前体分子被超极化，然后应用一个或多个无线电频率脉冲序列来在第一对核和第二对核之间转移自旋状态，从而提供非平衡单态核自旋种群。为了检测对比剂，另一个或多个无线电频率脉冲序列被应用来将单态序转移到极化。不需要对比剂的分子结构进行转换以进行检测。还描述了使用对比剂成像目标的方法。
• US9346795B2
  申请人：——

  公开号：US9346795B2

  公开（公告）日：2016-05-24
• US9642924B2
  申请人：——

  公开号：US9642924B2

  公开（公告）日：2017-05-09