(5E)-1-(4-methoxybenzyl)-5-(naphthalen-1-ylmethylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (5E)-1-(4-methoxybenzyl)-5-(naphthalen-1-ylmethylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
• 英文别名: (5E)-1-[(4-methoxyphenyl)methyl]-5-(naphthalen-1-ylmethylidene)-1,3-diazinane-2,4,6-trione
• 化学式: C₂₃H₁₈N₂O₄
• 分子量: 386.4
• InChiKey: CEACBNGIRLZOIZ-DEDYPNTBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  75.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Compositions and methods for treating diseases associated with uncontrolled inflammatory responses
  申请人：SF17 THERAPEUTICS, INC.

  公开号：US11147815B2

  公开（公告）日：2021-10-19

  Methods of treating, controlling or managing diseases associated with uncontrolled inflammatory responses are provided. These methods comprise the administration of small molecule compounds that alter the activity of Tripartite motif containing 8 (TRIM8) in blood monocytes. Also provided are pharmaceutical compositions that comprise small molecule compounds that specifically target the E2-RING domain or the RING-RING dimerization domain of TRIM8 for the treatment, control or management of diseases associated with uncontrolled inflammatory responses.

  本研究提供了治疗、控制或管理与不受控制的炎症反应有关的疾病的方法。这些方法包括施用改变血液单核细胞中含三方基序 8（TRIM8）活性的小分子化合物。还提供了药物组合物，其中包含特异性靶向 TRIM8 的 E2-RING 结构域或 RING-RING 二聚化结构域的小分子化合物，用于治疗、控制或管理与失控炎症反应相关的疾病。
• COMPOSITIONS AND METHODS FOR TREATING DISEASES ASSOCIATED WITH UNCONTROLLED INFLAMMATORY RESPONSES
  申请人：SF17 THERAPEUTICS, INC.

  公开号：US20210251993A1

  公开（公告）日：2021-08-19

  Methods of treating, controlling or managing diseases associated with uncontrolled inflammatory responses are provided. These methods comprise the administration of small molecule compounds that alter the activity of Tripartite motif containing 8 (TRIM8) in blood monocytes. Also provided are pharmaceutical compositions that comprise small molecule compounds that specifically target the E2-RING domain or the RING-RING dimerization domain of TRIM8 for the treatment, control or management of diseases associated with uncontrolled inflammatory responses.
• [EN] COMPOSITIONS AND METHODS FOR TREATING DISEASES ASSOCIATED WITH UNCONTROLLED INFLAMMATORY RESPONSES<br/>[FR] COMPOSITIONS ET MÉTHODES POUR TRAITER DES MALADIES ASSOCIÉES À DES RÉPONSES INFLAMMATOIRES NON CONTRÔLÉES
  申请人：SF17 THERAPEUTICS INC

  公开号：WO2020041533A1

  公开（公告）日：2020-02-27

  Methods of treating, controlling or managing diseases associated with uncontrolled inflammatory responses are provided. These methods comprise the administration of small molecule compounds that alter the activity of Tripartite motif containing 8 (TRIM8) in blood monocytes. Also provided are pharmaceutical compositions that comprise small molecule compounds that specifically target the E2-RING domain or the RING-RING dimerization domain of TRIM8 for the treatment, control or management of diseases associated with uncontrolled inflammatory responses.