2-Oxaspiro[3.5]nonan-5-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环丁烷
• 英文名称: 2-Oxaspiro[3.5]nonan-5-amine
• 英文别名: 2-oxaspiro[3.5]nonan-5-amine
• 化学式: C₈H₁₅NO
• 分子量: 141.21
• InChiKey: IXDKXBWIGNJCFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] DIHYDROTHIAZINE AND DIHYDROOXAZINE DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY<br/>[FR] DÉRIVÉS DE DIHYDROTHIAZINE ET DE DIHYDROOXAZINE PRÉSENTANT UNE ACTIVITÉ INHIBITRICE DE BACE1
  申请人：SHIONOGI & CO

  公开号：WO2015156421A1

  公开（公告）日：2015-10-15

  The present invention provides a compound which has an effect of inhibiting amyloid β production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or phylactic agent for diseases induced by production, secretion and/or deposition of amyloid β proteins. A compound of the formula (I) wherein X is -S- or -O-, R3a is alkyl, haloalkyl or the like, R2a is H, halogen, alkyloxy, haloalkyloxy or the like, R2b is H or the like, R3b is H or alkyl, ring A and ring B is each independently a substituted or unsubstituted aromatic carbocycle, a substituted or unsubstituted aromatic heterocycle or the like, and R1 is substituted or unsubstituted alkyl or the like, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种具有抑制淀粉样蛋白β产生作用的化合物，特别是抑制BACE1的作用，并且作为治疗或预防通过淀粉样蛋白β蛋白的产生、分泌和/或沉积引起的疾病的药物或预防剂而有用。其中化合物的结构式（I）中，X为-S-或-O-，R3a为烷基、卤代烷基或类似物，R2a为H、卤素、烷氧基、卤代烷氧基或类似物，R2b为H或类似物，R3b为H或烷基，环A和环B分别独立地为取代或未取代的芳香环烃、取代或未取代的芳香杂环或类似物，R1为取代或未取代的烷基或类似物，或其药学上可接受的盐。
• AZABENZIMIDAZOLE DERIVATIVE HAVING AMPK-ACTIVATING ACTIVITY
  申请人：Shionogi & Co., Ltd.

  公开号：EP2733141A1

  公开（公告）日：2014-05-21

  Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: or a pharmaceutically acceptable salt thereof, wherein R4 is hydrogen, or substituted or unsubstituted alkyl, R1, R2 and R3 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl or the like, with the proviso that R1, R2 and R3 are not simultaneously hydrogen, X is a single bond, -S-, -O-, -NR5-, -C(=O)- or the like, R5 is hydrogen, or substituted or unsubstituted alkyl, Y is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl or the like.

  本发明公开了一种可用作 AMPK 激活剂的化合物。 一种由式表示的化合物： 或其药学上可接受的盐、 其中 R4 是氢、或取代或未取代的烷基、 R1、R2 和 R3 各自独立地为氢、卤素、羟基、氰基、硝基、羧基、取代或未取代的烷基或类似物，但 R1、R2 和 R3 不能同时为氢、 X 是单键、-S-、-O-、-NR5-、-C(=O)- 等、 R5 是氢、取代或未取代的烷基、 Y 是取代或未取代的环烷基、取代或未取代的环烯基、取代或未取代的杂环基等。
• HIV REPLICATION INHIBITOR
  申请人：Shionogi & Co., Ltd.

  公开号：EP2952503A1

  公开（公告）日：2015-12-09

  The present invention provides a novel compound having an antiviral activity, in particular, an HIV replication inhibiting activity, as well as a pharmaceutical composition, in particular, an anti-HIV agent. wherein ring A is substituted or unsubstituted carbocycle or substituted or unsubstituted heterocycle; R1 is substituted or unsubstituted alkyl etc.; R2 is substituted or unsubstituted alkyloxy etc.; n is 1 or 2; R3 is substituted or unsubstituted carbocyclyl or substituted or unsubstituted heterocyclyl; R4 is a hydrogen atom etc.; R6 is substituted or unsubstituted alkyl etc.

  本发明提供了一种具有抗病毒活性，特别是抑制艾滋病毒复制活性的新型化合物，以及一种药物组合物，特别是一种抗艾滋病毒制剂。 其中环 A 是取代或未取代的碳环或取代或未取代的杂环；R1 是取代或未取代的烷基等；R2 是取代或未取代的烷氧基等；n 是 1 或 2；R3 是取代或未取代的碳环或取代或未取代的杂环；R4 是氢原子等；R6 是取代或未取代的烷基等。
• INDOLE AND AZAINDOLE DERIVATIVES EACH HAVING AMPK-ACTIVATING ACTIVITY
  申请人：Shionogi & Co., Ltd.

  公开号：EP2963013A1

  公开（公告）日：2016-01-06

  Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: or its pharmaceutically acceptable salt, wherein Y is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, or substituted or unsubstituted heterocyclyl; T is -CR7= or -N=; U is -CR8= or -N=; R2 is hydrogen, halogen, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted acyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted alkylthio, substituted or unsubstituted alkylsulfinyl, substituted or unsubstituted alkylsulfonyl, or substituted or unsubstituted alkyloxycarbonyl; R3 is halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl, or the like; and R4, R7 and R8 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl, or the like.

  本发明公开了一种可用作 AMPK 激活剂的化合物。一种由式表示的化合物： 或其药学上可接受的盐、 其中 Y 是取代或未取代的烷基、取代或未取代的烯基、取代或未取代的炔基、取代或未取代的芳基、取代或未取代的杂芳基、取代或未取代的环烷基、取代或未取代的环烯基、取代或未取代的杂环基； T 是-CR7= 或-N=； U 是-CR8= 或-N=； R2 是氢、卤素、氰基、硝基、羧基、取代或未取代的烷基、取代或未取代的烯基、取代或未取代的酰基、取代或未取代的氨基甲酰基、取代或未取代的烷硫基、取代或未取代的烷硫基、取代或未取代的烷磺酰基、取代或未取代的烷氧羰基； R3 是卤素、取代或未取代的烷基、取代或未取代的烯基、取代或未取代的炔基、取代或未取代的芳基、取代或未取代的杂芳基、取代或未取代的环烷基、取代或未取代的环烯基、取代或未取代的杂环基，或类似物；和 R4、R7 和 R8 各自独立地为氢、卤素、羟基、氰基、硝基、羧基、取代或未取代的烷基、取代或未取代的烯基、取代或未取代的炔基、取代或未取代的芳基、取代或未取代的杂芳基、取代或未取代的环烷基、取代或未取代的环烯基、取代或未取代的杂环基或类似物。
• NUCLEOSIDE AND NUCLEOTIDE, HAVING NITROGEN-CONTAINING HETERCYCLE STRUCTURE
  申请人：Shionogi & Co., Ltd.

  公开号：EP2957567A1

  公开（公告）日：2015-12-23

  The present invention provides compounds shown by the formula: wherein Y1 is CR6 or N, Y2 is CR7 or N, Y3 is CR8 or N, R6, R7 and R8 are each independently, a hydrogen atom, halogen, cyano, substituted or unsubstituted alkyl or the like, Bx is a nucleic acid base moiety, Z1 and Z2 are each independently, a hydrogen atom, a hydroxyl protecting group or a reactive phosphorus group, R1 to R5 are each independently, a hydrogen atom, halogen, cyano, substituted or unsubstituted alkyl or the like, and n is an integer of 0 to 3, or salts thereof, that are novel nucleosides or nucleotides that can be useful as materials for synthesizing nucleic acid pharmaceuticals.

  本发明提供的化合物如式所示： 其中 Y1 是 CR6 或 N Y2 是 CR7 或 N Y3 是 CR8 或 N、 R6、R7 和 R8 各自独立地为氢原子、卤素、氰基、取代或未取代的烷基或类似物、 Bx 是核酸碱基、 Z1 和 Z2 各自独立地为氢原子、羟基保护基团或活性磷基团、 R1 至 R5 各自独立地为氢原子、卤素、氰基、取代或未取代的烷基或类似基团，以及 n 是 0 至 3 的整数、 或其盐，它们是新型核苷或核苷酸，可用作合成核酸药物的材料。