2-Phenyl-2-propyl-bernsteinsaeure | 75542-33-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 2-Phenyl-2-propyl-bernsteinsaeure
• 英文别名: α-Propyl-α-phenyl-bernsteinsaeure；(+/-)-α-Phenyl-α-propylbernsteinsaeure；2-phenyl-2-propyl-succinic acid；2-Phenyl-2-propylsuccinic acid；2-phenyl-2-propylbutanedioic acid
• CAS: 75542-33-5
• 化学式: C₁₃H₁₆O₄
• 分子量: 236.268
• InChiKey: AOLREBWZLIOCII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Phenyl-2-propyl-bernsteinsaeure 在 氨 、 水 作用下， 生成 3-苯基-3-丙基吡咯烷-2,5-二酮
  参考文献：
  名称：

  Anticonvulsants. I. An Investigation of N-R-α-R₁-α-Phenylsuccinimides

  摘要：

  DOI：

  10.1021/ja01154a126
• 作为产物：
  描述：

  3-Phenyl-3-cyan-capronsaeure-t-butylester 生成 2-Phenyl-2-propyl-bernsteinsaeure
  参考文献：
  名称：

  Makosza,M., Roczniki Chemii, 1969, vol. 43, p. 79 - 86

  摘要：

  DOI：

文献信息

• [EN] PHTHALAZINONE DERIVATIVES<br/>[FR] DERIVES DE PHTHALAZINONE
  申请人：KUDOS PHARM LTD

  公开号：WO2003093261A1

  公开（公告）日：2003-11-13

  A compound of formula (I); or an isomer, salt, solvate, chemically protected form, or prodrug thereof, wherein A and B together represent an optionally substituted, fused aromatic ring; RL is a C5-7 aryl group substituted in the meta position by the group R2, and optionally further substituted; wherein R2 is selected from formula (II) and formula (III); and its use as a pharmaceutical, in particular for the treatment of diseases ameliorated by inhibiting the activity of PARP.

  一种具有化学式（I）的化合物；或其异构体、盐、溶剂合物、化学保护形式、或前药，其中A和B共同代表一个可选择取代的融合芳香环；RL是一个C5-7芳基基团，在邻位由基团R2取代，并可选择进一步取代；其中R2选自化学式（II）和化学式（III）；以及其作为药物的用途，特别用于治疗通过抑制PARP活性改善的疾病。
• New antiarrhythmic agents. 4. 1'-(aminoalkyl)-1,2,3,4-tetrahydronaphthalene-1-spiro-3'-pyrrolidine-2',5'-dione derivatives
  作者：Paul A. Tenthorey、Robert A. Ronfeld、Hal S. Feldman、Rune V. Sandberg、Paul D. McMaster、Emil R. Smith

  DOI：10.1021/jm00133a011

  日期：1981.1

  induced myocardial infarctions. All produced distinct antiarrhythmic effects at doses considerably lower than doses of lidocaine or tocainide producing comparable effects. The principal toxic effects observed in dogs were convulsion and depression of intracardiac conduction; they occurred generally at higher doses than those leading to antiarrhythmic effect. Several compounds also suppressed digitalis-induced

  测试了一系列33种1'-（氨基烷基）-1,2,3,4-四氢萘-1-螺-3'-吡咯烷-2'，5'-二酮衍生物在小鼠和狗中的抗心律失常和毒性作用。在小鼠中，以100 mg / kg的皮下剂量，有31种化合物对氯仿诱导的快速性心律失常产生了一定的保护作用，在保护80％或以上的动物剂量下，有6种化合物没有产生可检测的毒性。在有手术诱发的心肌梗塞的狗中测试了七种更有效且无毒的衍生物。全部产生明显的抗心律失常作用，其剂量明显低于产生可比作用的利多卡因或托卡因的剂量。在狗中观察到的主要毒性作用是惊厥和心内传导抑制。它们的发生剂量通常高于导致抗心律失常作用的剂量。几种化合物还可以抑制麻醉犬的洋地黄引起的心律不齐。确定了三种化合物在狗中的半衰期和总的体内清除率。在临床试验中，两种药物的半衰期可与长效口服活性抗心律失常药托卡尼特相当。
• Phthalazinone derivatives
  申请人：KuDOS Pharmaceuticals Limited

  公开号：US20040023968A1

  公开（公告）日：2004-02-05

  A compound of formula: 1 or an isomer, salt, solvate, chemically protected form, or prodrug thereof, wherein A and B together represent an optionally substituted, fused aromatic ring; R L is a C 5-7 aryl group substituted in the meta position by the group R 2 , and optionally further substituted; wherein R 2 is selected from: 2 and its use as a pharmaceutical, in particular for the treatment of diseases ameliorated by inhibiting the activity of PARP.

  一种化合物，其分子式为1或其异构体、盐、溶剂合物、化学保护形式或前药，其中A和B在一起代表一个可选取代的融合芳香环；RL是一个C5-7芳基基团，在meta位被R2基团取代，且可选取进一步取代；其中R2被选自：2，并且它被用作一种药物，特别是用于治疗通过抑制PARP活性改善的疾病。
• Polyester containing tertiary carboxyl groups, process for its preparation and thermosetting powder compositions containing it
  申请人：——

  公开号：US20030148130A1

  公开（公告）日：2003-08-07

  The invention concerns a polyester bearing tertiary carboxyl groups, characterised in that it consists of: (a) 8.1 to 35 moles of an aliphatic or cycloaliphatic of a polyol; (b) 9.1 to 36 moles of an aliphatic, cycloaliphatic or aromatic polycarboxylic acid; (c) 1.6 to 2.8 moles of an aliphatic, cycloaliphatic or aromatic compound comprising a tertiary carboxyl group and either a primary or secondary carboxyl group, or a primary or secondary hydroxyl group. Said polyester is prepared in several steps, the first steps consisting in the preparation of a polyester by condensation between (a) an aliphatic or cycloaliphatic polyol, and (b) an aliphatic, cycloaliphatic or aromatic polycarboxylic acid, the final step consisting in condensing said polyester with (c) an aliphatic, cycloaliphatic or aromatic compound comprising a tertiary carboxyl group and either a primary or secondary carboxyl group, or a primary or secondary hydroxyl group. Said polyester is used in thermosetting powder compositions, mixed with a crosslinking agent which is more particularly a &bgr;-hydroxylalkylarnide. Said compositions provide coatings with excellent surface appearance, good flexibility and good resistance to poor weather conditions.

  本发明涉及一种带有叔羧基的聚酯，其特征在于它包括(a) 8.1 至 35 摩尔的脂肪族或环脂族多元醇； (b) 9.1 至 36 摩尔的脂肪族、环脂族或芳香族多元羧酸； (c) 1.6 至 2.8 摩尔的脂肪族、环脂族或芳香族化合物，该化合物包含一个叔羧基和一个伯或 仲羧基，或一个伯或仲羟基。聚酯的制备分为几个步骤，第一步是通过缩合(a)脂肪族或环脂族多元醇和(b)脂肪族、环脂族或芳香族多羧酸制备聚酯，最后一步是将聚酯与(c)脂肪族、环脂族或芳香族化合物缩合，该化合物包含叔羧基和伯、仲羧基，或伯、仲羟基。所述聚酯用于热固性粉末组合物中，并与交联剂混合，交联剂尤其是羟基烷基酰胺。所述组合物提供的涂层具有极佳的表面外观、良好的柔韧性和良好的耐恶劣气候条件性能。
• Bellomonte; Rosnati, Gazzetta Chimica Italiana, 1959, vol. 89, p. 1237,1241
  作者：Bellomonte、Rosnati

  DOI：——

  日期：——