5-[[6-[(6-Methoxy-1-methylbenzimidazol-2-yl)methoxy]naphthalen-2-yl]methyl]-1,3-thiazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-[[6-[(6-Methoxy-1-methylbenzimidazol-2-yl)methoxy]naphthalen-2-yl]methyl]-1,3-thiazolidine-2,4-dione
• 英文别名: 5-[[6-[(6-methoxy-1-methylbenzimidazol-2-yl)methoxy]naphthalen-2-yl]methyl]-1,3-thiazolidine-2,4-dione
• 化学式: C₂₄H₂₁N₃O₄S
• 分子量: 447.5
• InChiKey: FWDCARKULUWBKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• METHODS AND COMPOSITIONS FOR LOCALLY INCREASING BODY FAT
  申请人：Topokine Therapeutics, Inc.

  公开号：US20140142075A1

  公开（公告）日：2014-05-22

  Provided are methods for increasing fat locally in a body of a subject in need thereof comprising percutaneously administering to the subcutaneous fat of the subject a thiazolidinedione or an orexigenic compound, or a pharmaceutically acceptable salt or prodrug thereof, optionally delivered as a composition comprising a pharmaceutically acceptable carrier, as described herein. In certain embodiments, the pharmaceutically acceptable carrier comprises a percutaneous carrier, as described herein. Further provided are compositions comprising a thiazolidinedione or an orexigenic compound, or a pharmaceutically acceptable salt or prodrug thereof, for use according to the invention.
• US8778981B2
  申请人：——

  公开号：US8778981B2

  公开（公告）日：2014-07-15
• US8883834B2
  申请人：——

  公开号：US8883834B2

  公开（公告）日：2014-11-11