1,2,3-Trifluoro-3-pentyldiaziridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环化合物
• 英文名称: 1,2,3-Trifluoro-3-pentyldiaziridine
• 英文别名: 1,2,3-trifluoro-3-pentyldiaziridine
• 化学式: C₆H₁₁F₃N₂
• 分子量: 168.16
• InChiKey: XBIZYIXSIJFOCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Photoactive bioadhesive compositions
  申请人：Nanyang Technological University

  公开号：US10005936B2

  公开（公告）日：2018-06-26

  A novel diazirine-based biocompatible polymer that can be used as on-demand or tunable bioadhesive and applied across various clinically important surfaces. The biocompatible polymer comprises a single strand of repeating units and up to 5,000 photoreactive diazirine groups covalently attached to it. A bioadhesive composition comprises the polymer of the present invention and suitable solvents, surfactants, stabilizers, fillers and other additives. The composition may additionally contain metallic particles of size less than 50 micron made of rare earth elements and has UV or NIR transparency less than 1 optical density unit per 1 centimeter. The poly-diazirine surface grafted thin films can be used for minimally invasive surgeries.

  一种新型重氮基生物相容性聚合物，可用作按需或可调生物粘合剂，应用于各种重要的临床表面。这种生物相容性聚合物由单股重复单元和多达 5,000 个共价连接的光活性重氮氨酸基团组成。生物粘合剂组合物由本发明的聚合物和合适的溶剂、表面活性剂、稳定剂、填料和其他添加剂组成。此外，该组合物还可能含有由稀土元素制成的尺寸小于 50 微米的金属颗粒，其紫外线或近红外透明度小于每 1 厘米 1 个光密度单位。聚二氮杂环胺表面接枝薄膜可用于微创手术。
• New Photoactive Bioadhesive Compositions
  申请人：NANYANG TECHNOLOGICAL UNIVERSITY

  公开号：US20150315434A1

  公开（公告）日：2015-11-05

  A novel diazirine-based biocompatible polymer that can be used as on-demand or tunable bioadhesive and applied across various clinically important surfaces. The biocompatible polymer comprises a single strand of repeating units and up to 5,000 photoreactive diazirine groups covalently attached to it. A bioadhesive composition comprises the polymer of the present invention and suitable solvents, surfactants, stabilizers, fillers and other additives. The composition may additionally contain metallic particles of size less than 50 micron made of rare earth elements and has UV or NIR transparency less than 1 optical density unit per 1 centimetre. The poly-diazirine surface grafted thin films can be used for minimally invasive surgeries.
• [EN] NEW PHOTOACTIVE BIOADHESIVE COMPOSITIONS<br/>[FR] NOUVELLES COMPOSITIONS BIOADHÉSIVES PHOTOACTIVES
  申请人：UNIV NANYANG TECH

  公开号：WO2014081391A1

  公开（公告）日：2014-05-30

  A novel diazirine-based biocompatible polymer that can be used as on-demand or tuneable bioadhesive and applied across various clinically important surfaces. The biocompatible polymer comprises a single strand of repeating units and up to 5,000 photoreactive diazirine groups covalently attached to it. A bioadhesive composition comprises the polymer of the present invention and suitable solvents, surfactants, stabilizers, fillers and other additives. The composition may additionally contain metallic particles of size less than 50 micron made of rare earth elements and has UV or NIR transparency less than 1 optical density unit per 1 centimetre. The poly-diazirine surface grafted thin films can be used for minimally invasive surgeries.