2-(1-methylindazol-3-yl)-N-[5-[4-[5-[[2-(1-methylindazol-3-yl)acetyl]amino]-1,3,4-thiadiazol-2-yl]butyl]-1,3,4-thiadiazol-2-yl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 2-(1-methylindazol-3-yl)-N-[5-[4-[5-[[2-(1-methylindazol-3-yl)acetyl]amino]-1,3,4-thiadiazol-2-yl]butyl]-1,3,4-thiadiazol-2-yl]acetamide
• 化学式: C₂₈H₂₈N₁₀O₂S₂
• 分子量: 600.7
• InChiKey: HXRVCUUPKHIXOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  42
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  202
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• GLUTAMASE INHIBITORS AND METHOD OF USE
  申请人：AGIOS PHARMACEUTICALS, INC.

  公开号：US20150299152A1

  公开（公告）日：2015-10-22

  Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.

  本文描述了抑制谷氨酰胺酶的化合物和组合物。本文还描述了使用抑制谷氨酰胺酶的化合物治疗癌症的方法。
• Glutaminase inhibitors and method of use
  申请人：AGIOS PHARMACEUTICALS, INC.

  公开号：US10011574B2

  公开（公告）日：2018-07-03

  Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.

  本文描述了包含抑制谷氨酰胺酶的化合物和组合物。本文还描述了使用抑制谷氨酰胺酶的化合物治疗癌症的方法。
• GLUTAMINASE INHIBITORS AND METHODS OF USE
  申请人：Agios Pharmaceuticals, Inc.

  公开号：EP2922832B1

  公开（公告）日：2019-10-09
• [EN] GLUTAMASE INHIBITORS AND METHOD OF USE<br/>[FR] INHIBITEURS DE GLUTAMASE ET LEUR PROCÉDÉ D'UTILISATION
  申请人：AGIOS PHARMACEUTICALS INC

  公开号：WO2014081925A1

  公开（公告）日：2014-05-30

  Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.