(E)-3-[1-[(3,5-dichlorophenyl)methyl]-6-(trifluoromethyl)indazol-3-yl]prop-2-enoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: (E)-3-[1-[(3,5-dichlorophenyl)methyl]-6-(trifluoromethyl)indazol-3-yl]prop-2-enoic acid
• 化学式: C₁₈H₁₁Cl₂F₃N₂O₂
• 分子量: 415.2
• InChiKey: XBOQKMPDLKVBQT-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  55.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Methods of treating a metabolic syndrome by modulating heat shock protein (HSP) 90-beta
  申请人：Berg LLC

  公开号：US10023864B2

  公开（公告）日：2018-07-17

  The invention provides HSP90β inhibitors comprising an antisense oligonucleotide targeting HSP90β, pharmaceutical compositions comprising said inhibitors and methods of treatment of a metabolic syndrome by administering said HSP90β inhibitors to a subject in need thereof. The antisense oligonucleotides may be targeted to skeletal muscle.

  本发明提供了由靶向 HSP90β 的反义寡核苷酸组成的 HSP90β 抑制剂、由所述抑制剂组成的药物组合物以及通过向有需要的受试者施用所述 HSP90β 抑制剂来治疗代谢综合征的方法。反义寡核苷酸可靶向骨骼肌。
• METHODS OF TREATING A METABOLIC SYNDROME BY MODULATING HEAT SHOCK PROTEIN (HSP) 90-BETA
  申请人：Narain Niven Rajin

  公开号：US20140154266A1

  公开（公告）日：2014-06-05

  The invention provides methods of treatment of metabolic syndrome with HSP90 inhibitors, particularly HSP90β inhibitors. The invention provides methods of diagnosis and monitoring of metabolic syndrome using HSP90, particularly HSP90β, expression and activity level.