2-acetyl-3-chloro-4-(dimethylamino)-10,11,12a-trihydroxy-6,9-dimethyl-4a,5-dihydro-4H-tetracene-1,12-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-acetyl-3-chloro-4-(dimethylamino)-10,11,12a-trihydroxy-6,9-dimethyl-4a,5-dihydro-4H-tetracene-1,12-dione
• 化学式: C₂₄H₂₄ClNO₆
• 分子量: 457.9
• InChiKey: GQJHMPQHCTYJCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  32
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• SUBSTITUTED TETRACYCLINE COMPOUNDS
  申请人：Abato Paul

  公开号：US20140155357A1

  公开（公告）日：2014-06-05

  The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.