N,N-dimethyl-4-phenyl-1-piperazinecarboxamide | 127571-10-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N,N-dimethyl-4-phenyl-1-piperazinecarboxamide
• 英文别名: 1-phenyl-4-dimethylcarbamoylpiperazine；N,N-dimethyl-4-phenylpiperazine-1-carboxamide
• CAS: 127571-10-2
• 化学式: C₁₃H₁₉N₃O
• mdl: MFCD06154287
• 分子量: 233.313
• InChiKey: HLZITXQUFINJSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  26.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-苯基哌嗪 、 二甲氨基甲酰氯 在 吡啶 作用下， 以 苯 为溶剂， 以32%的产率得到N,N-dimethyl-4-phenyl-1-piperazinecarboxamide
  参考文献：
  名称：

  Synthesis and antiallergy activity of N-[2-(dimethylamino)ethyl]-4-aryl-1-piperazinecarboxamide derivatives

  摘要：

  A series of N-[2-(dimethylamino)ethyl]-4-aryl-1-piperazinecarboxamides was synthesized and evaluated for antiallergy activity. Several derivatives had activity in the passive foot anaphylaxis (PFA) assay, an IgE-mediated model useful in the detection of compounds possessing antiallergic activity, but no derivative tested had activity at 10 mg/kg in the guinea pig anaphylaxis (GPA) assay. One analogue, N-[2-(dimethylamino)ethyl]-4-(4-fluorophenyl)-1-piperazinecarboxamide , had an IC50 = 310 nM for inhibition of tritiated mepyramine binding to H1 histaminic receptors isolated from guinea pig cerebral cortex.

  DOI：

  10.1021/jm00169a037

文献信息

• WALSH, DAVID A.;GREEN, JERRY B.;FRANZYSHEN, STEPHEN K.;NOLAN, JOSEPH C.;Y+, J. MED. CHEM., 33,(1990) N, C. 2028-2032
  作者：WALSH, DAVID A.、GREEN, JERRY B.、FRANZYSHEN, STEPHEN K.、NOLAN, JOSEPH C.、Y+

  DOI：——

  日期：——
• US4446133A
  申请人：——

  公开号：US4446133A

  公开（公告）日：1984-05-01