1,3,4,9-Tetrahydrocyclopenta[b]naphthalen-2-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1,3,4,9-Tetrahydrocyclopenta[b]naphthalen-2-one
• 英文别名: 1,3,4,9-tetrahydrocyclopenta[b]naphthalen-2-one
• 化学式: C₁₃H₁₂O
• 分子量: 184.23
• InChiKey: UOUVSQJDYAVGFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• METHODS OF SYNTHESIZING A PROSTACYCLIN ANALOG
  申请人：Cayman Chemical Company, Incorporated

  公开号：EP2928858A2

  公开（公告）日：2015-10-14
• [EN] METHODS OF SYNTHESIZING A PROSTACYCLIN ANALOG<br/>[FR] PROCÉDÉS DE SYNTHÈSE D'UN ANALOGUE DE PROSTACYCLINE
  申请人：CAYMAN CHEMICAL CO INC

  公开号：WO2014089385A2

  公开（公告）日：2014-06-12

  The present invention provides processes for preparing a prostacyclin analogue of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.