(1aS,7aS)-7-(hydroxyamino)-N-phenyl-7,7a-dihydro-1H-cyclopropa[b]chromene-1a-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (1aS,7aS)-7-(hydroxyamino)-N-phenyl-7,7a-dihydro-1H-cyclopropa[b]chromene-1a-carboxamide
• 化学式: C₁₇H₁₆N₂O₃
• 分子量: 296.32
• InChiKey: DJSNLCIRQCAIMH-YRFPZCSCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  70.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• METHOD AND COMPOSITION FOR CRYSTALLIZING A GPCR
  申请人：ConfometRx, Inc.

  公开号：US20140162341A1

  公开（公告）日：2014-06-12

  Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising, from N-terminus to C-terminus: a) a first portion of a family C G-protein coupled receptor (GPCR), wherein the first portion comprises the TM1, TM2 and TM3, regions of the GPCR; b) a stable, folded protein insertion; and c) a second portion of the GPCR, wherein the second portion comprises the TM4, TM5 TM6 and TM7 regions of the GPCR.
• METHOD FOR ANALYZING THE THREE DIMENSIONAL STRUCTURE OF A GPCR
  申请人：ConfometRx, Inc.

  公开号：US20150057166A1

  公开（公告）日：2015-02-26

  Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising, from N-terminus to C-terminus: a) a first portion of a family C G-protein coupled receptor (GPCR), wherein the first portion comprises the TM1, TM2 and TM3, regions of the GPCR; b) a stable, folded protein insertion; and c) a second portion of the GPCR, wherein the second portion comprises the TM4, TM5 TM6 and TM7 regions of the GPCR.
• US8889377B2
  申请人：——

  公开号：US8889377B2

  公开（公告）日：2014-11-18