(6-bromopyrazolo[1,5-a]pyrimidin-2-yl)(3,4-dihydroisoquinolin-2(1H)-yl)methanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: (6-bromopyrazolo[1,5-a]pyrimidin-2-yl)(3,4-dihydroisoquinolin-2(1H)-yl)methanone
• 英文别名: (6-bromopyrazolo[1,5-a]pyrimidin-2-yl)-(3,4-dihydro-1H-isoquinolin-2-yl)methanone
• 化学式: C₁₆H₁₃BrN₄O
• 分子量: 357.2
• InChiKey: PPFVMPKRZPPZFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  50.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Pyrazolopyrimidines, a process for their preparation and their use as medicine
  申请人：Danysz Wojciech

  公开号：US20080032998A1

  公开（公告）日：2008-02-07

  Substituted pyrazolopyrimidine derivatives of formula (I) wherein R 1 represents chloro or bromo; R 2 , R 3 , R 4 , R 5 , R 6 and R 7 independently represent e.g. hydrogen or C 1-6 -alkyl; R 8 represents a radical R 9 or a radical R 10 , whereby one of the two radicals R 8 represents R 9 and the other radical R 8 represents Ret; R 9 represents e.g. a phenyl or thiophene group, and R 10 represents e.g. hydrogen or methyl; are potent mGluR5 modulators and are useful for the prevention of acute and chronic neurological disorders.

  取代吡唑并嘧啶衍生物的公式(I) 其中 R1代表氯或溴； R2、R3、R4、R5、R6和R7独立代表例如氢或C1-6-烷基； R8代表R9的基团或R10的基团，其中两个R8基团之一代表R9，另一个R8基团代表Ret；R9代表例如苯基或噻吩基团，R10代表例如氢或甲基； 是有效的mGluR5调节剂，可用于预防急性和慢性神经障碍。
• Substituted pyrazolopyrimidines, a process for their preparation and their use as medicine
  申请人：Danysz Wojciech

  公开号：US20080039458A1

  公开（公告）日：2008-02-14

  Substituted pyrazolopyrimidine derivatives of formula (I) wherein Y 1 , Y 2 , Y 3 , Y 4 represent N or C—, whereby at least two of the groups Y 1 to Y 4 represent a carbon atom, R 1 represents chloro or bromo, R 2 to R 7 represent e.g. hydrogen, methyl or ethyl; and R 10 and R 11 independently represent e.g. hydrogen or C 1 -C 6 alkyl, are potent mGluR5 modulators and are useful for the prevention of acute and chronic neurological disorders.

  式(I)中的取代嘧唑嘧啶衍生物，其中Y1、Y2、Y3、Y4代表N或C—，其中至少两个Y1到Y4代表碳原子，R1代表氯或溴，R2到R7代表氢、甲基或乙基等，而R10和R11独立地代表氢或C1-C6烷基。这些衍生物是有效的mGluR5调节剂，并可用于预防急性和慢性神经系统疾病。
• Pyrazolopyrimidines for treating CNS disorders
  申请人：Danysz Wojciech

  公开号：US20110212956A1

  公开（公告）日：2011-09-01

  Substituted pyrazolopyrimidine derivatives of formula (I) wherein Y 1 , Y 2 , Y 3 , Y 4 represent N or C—, whereby at least two of the groups Y 1 to Y 4 represent a carbon atom, R 1 represents chloro or bromo, R 2 to R7 represent e.g. hydrogen, methyl or ethyl; and R 10 and R 11 independently represent e.g. hydrogen or C 1 -C 6 alkyl, are potent mGluR5 modulators and are useful for the prevention of acute and chronic neurological disorders.

  公式（I）的替代嘧唑嘧啶衍生物，其中Y1，Y2，Y3，Y4代表N或C-，其中至少有两个Y1至Y4代表碳原子，R1代表氯或溴，R2至R7代表氢，甲基或乙基等基团; 而R10和R11分别代表氢或C1-C6烷基，是有效的mGluR5调节剂，并可用于预防急性和慢性神经系统疾病。
• PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE
  申请人：Henrich Markus

  公开号：US20110003820A1

  公开（公告）日：2011-01-06

  The invention relates to pyrazolopyrimidine derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are mGluR5 modulators and are therefore useful for the control and prevention of acute and/or chronic neurological disorders.

  本发明涉及吡唑并嘧啶衍生物及其药学上可接受的盐。本发明还涉及制备这些化合物的方法。本发明的化合物是mGluR5调节剂，因此对于控制和预防急性和/或慢性神经系统疾病有用。
• SUBSTITUTED PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE
  申请人：Merz Pharma GmbH & Co. KGaA

  公开号：EP2054416A1

  公开（公告）日：2009-05-06