N,N,2,2-tetramethyl-3-[4-(naphthalen-2-ylamino)phenyl]propanamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N,N,2,2-tetramethyl-3-[4-(naphthalen-2-ylamino)phenyl]propanamide
• 化学式: C₂₃H₂₆N₂O
• 分子量: 346.5
• InChiKey: VAGYQCQISRBOKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] COMPOSITIONS AND METHODS FOR TREATING DISEASE<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE MALADIE
  申请人：ANGION BIOMEDICA CORP

  公开号：WO2014093960A1

  公开（公告）日：2014-06-19

  Methods are provided for treating fibrotic diseases and conditions and cancer and other dysproliferative diseases by administering to a subject in need there of a therapeutically effective amount of a composition comprising a retinol, or a pharmaceutically acceptable ester, salt or prodrug thereof; and a CYP26 inhibitor, or a pharmaceutically acceptable ester, salt or prodrug thereof; wherein said therapeutically effective amount suppresses fibrosis or the growth of dysproliferative cells in vivo. Compositions comprising a combination of a retinol, or a pharmaceutically acceptable ester, salt or prodrug thereof; and a CYP26 inhibitor a pharmaceutically acceptable ester, salt or prodrug thereof are also described.