5,6-dimethyl-3,4-dihydro-2H-chromen-8-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 5,6-dimethyl-3,4-dihydro-2H-chromen-8-amine
• 化学式: C₁₁H₁₅NO
• 分子量: 177.24
• InChiKey: BTLAXBMMGQKGIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Polycyclic inhibitor of anaplastic lymphoma kinase
  申请人：XUANZHU PHARMA CO., LTD.

  公开号：US10011592B2

  公开（公告）日：2018-07-03

  Disclosed is a polycyclic inhibitor of anaplastic lymphoma kinase as represented by Formula (I), or a pharmaceutically acceptable salt or stereoisomer thereof. Also disclosed is a method for preparing the compound, a pharmaceutical preparation and a pharmaceutical composition comprising the compound, and use of the compound, the pharmaceutically acceptable salt or stereoisomer thereof in manufacture of a medicament for the treatment and/or prevention of, for example, an anaplastic lymphoma kinase-mediated cancer or non-cancer related diseases.

  本发明公开了一种由式（I）表示的无性淋巴瘤激酶多环抑制剂或其药学上可接受的盐或立体异构体。还公开了一种制备该化合物的方法、一种药物制剂和一种包含该化合物的药物组合物，以及该化合物、其药学上可接受的盐或立体异构体在制造治疗和/或预防例如无性淋巴瘤激酶介导的癌症或非癌症相关疾病的药物中的用途。
• INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
  申请人：Gilead Sciences, Inc.

  公开号：EP2220046B1

  公开（公告）日：2014-06-18
• POLYCYCLIC INHIBITOR OF ANAPLASTIC LYMPHOMA KINASE
  申请人：XUANZHU PHARMA CO., LTD.

  公开号：US20170240534A1

  公开（公告）日：2017-08-24

  Disclosed is a polycyclic inhibitor of anaplastic lymphoma kinase as represented by Formula (I), or a pharmaceutically acceptable salt or stereoisomer thereof. Also disclosed is a method for preparing the compound, a pharmaceutical preparation and a pharmaceutical composition comprising the compound, and use of the compound, the pharmaceutically acceptable salt or stereoisomer thereof in manufacture of a medicament for the treatment and/or prevention of, for example, an anaplastic lymphoma kinase-mediated cancer or non-cancer related diseases.