4-chloro-N-[(1R)-1-naphthalen-1-ylethyl]-3,5-dinitrobenzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-chloro-N-[(1R)-1-naphthalen-1-ylethyl]-3,5-dinitrobenzamide
• 化学式: C19H14ClN3O5
• 分子量: 399.8
• InChiKey: PCKTWDVAPBYINT-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  121
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Chiral stationary phases based on derivatives of 4-amino-3,5-dinitrobenzoic acid
  申请人：——

  公开号：US20040144708A1

  公开（公告）日：2004-07-29

  The invention describes new chiral stationary phases containing a 4-amino-3,5-dinitrobenzoic unit modified with chiral groups and spacer groups. The invention includes the process for the perparation of said stationary phases starting from 4-halogenated derivative of 3,5-dinitrobenzoic acid, chiral selectors obtainable as intermediates in the aforesaid process, and the use of the chiral stationary phases in the separation of enantiomers.

  该发明描述了一种含有手性基团和间隔基团改性的4-氨基-3,5-二硝基苯甲酸单元的新手性固定相。该发明包括从3,5-二硝基苯甲酸的4-卤代衍生物开始制备所述固定相的过程，可在上述过程中获得的手性选择剂，以及在对映体分离中使用手性固定相的用途。
• CHIRAL STATIONARY PHASES BASED ON DERIVATIVES OF 4-AMINO-3,5-DINITROBENZOIC ACID
  申请人：EURAND PHARMACEUTICALS LTD.

  公开号：EP1370356A1

  公开（公告）日：2003-12-17
• US7018537B2
  申请人：——

  公开号：US7018537B2

  公开（公告）日：2006-03-28
• [EN] CHIRAL STATIONARY PHASES BASED ON DERIVATIVES OF 4-AMINO-3,5-DINITROBENZOIC ACID<br/>[FR] PHASES STATIONNAIRES CHIRALES A BASE DE DERIVES D'ACIDE 4-AMINO-3,5-DINITROBENZOIQUE
  申请人：EURAND PHARMACEUTICALS LTD

  公开号：WO2002070124A1

  公开（公告）日：2002-09-12

  The invention describes new chiral stationary phases containing a 4-amino-3,5-dinitrobenzoic unit modified with chiral groups and spacer groups. The invention includes the process for the perparation of said stationary phases starting from 4-halogenated derivative of 3,5-dinitrobenzoic acid, chiral selectors obtainable as intermediates in the aforesaid process, and the use of the chiral stationary phases in the separation of enantiomers.