(1R,2S)-1-[(4R,5R)-5-hydroxy-2-phenyl-1,3-dioxan-4-yl]butane-1,2-diol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: (1R,2S)-1-[(4R,5R)-5-hydroxy-2-phenyl-1,3-dioxan-4-yl]butane-1,2-diol
• 化学式: C₁₄H₂₀O₅
• 分子量: 268.3
• InChiKey: WBNYRZGZPVLYLK-WDIAWBBUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  79.2
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• CHLORO-PYRAZINE CARBOXAMIDE DERIVATIVES WITH EPITHELIAL SODIUM CHANNEL BLOCKING ACTIVITY
  申请人：Parion Sciences, Inc.

  公开号：US20140171447A1

  公开（公告）日：2014-06-19

  This invention provides compounds of the formula I: and their pharmaceutically acceptable salts, useful as sodium channel blockers, compositions containing the same, therapeutic methods and uses for the same and processes for preparing the same.

  这项发明提供了式I的化合物及其药用盐，可用作钠通道阻滞剂，包含这些化合物的组合物，以及用于这些化合物的治疗方法和用途，以及制备这些化合物的方法。
• 3,5-DIAMINO-6-CHLORO-N-(N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2- CARBOXAMIDE COMPOUNDS
  申请人：Parion Sciences, Inc.

  公开号：US20140170244A1

  公开（公告）日：2014-06-19

  The present invention relates compounds of the formula: or pharmaceutically acceptable salts thereof, useful as sodium channel blockers, as well as compositions containing the same, processes for the preparation of the same, and therapeutic methods of use therefore in promoting hydration of mucosal surfaces and the treatment of diseases including cystic fibrosis, chronic obstructive pulmonary disease, asthma, bronchiectasis, acute and chronic bronchitis, emphysema, and pneumonia.

  本发明涉及以下式的化合物： 或其药用可接受的盐，用作钠通道阻滞剂，以及含有相同化合物的组合物，制备相同化合物的方法，以及在促进粘膜表面水合和治疗包括囊性纤维化、慢性阻塞性肺病、哮喘、支气管扩张、急性和慢性支气管炎、肺气肿和肺炎等疾病的治疗方法。
• DITHIOL MUCOLYTIC AGENTS
  申请人：Johnson Michael R.

  公开号：US20150056305A1

  公开（公告）日：2015-02-26

  Provided are dithiol mucolytic agents. These agents increase the liquefaction of mucus in a patient with excessive mucus or mucus with increased viscoelastic, cohesive, or adhesive properties. Also provided are a variety of methods of treatment using these inventive mucolytic agents.

  提供了二硫醚粘液溶解剂。这些剂增加了病人体内过多黏液或具有增加的粘弹性、黏着性或粘附性的黏液的液化。还提供了使用这些创新黏液溶解剂的各种治疗方法。
• ARYLALKYL- AND ARYLOXYALKYL-SUBSTITUTED EPITHELIAL SODIUM CHANNEL BLOCKING COMPOUNDS
  申请人：Parion Sciences, Inc.

  公开号：US20150166487A1

  公开（公告）日：2015-06-18

  The present invention relates to the compound of the formula: or pharmaceutically acceptable salts thereof, as well as compositions containing the same, processes for the preparation of the same, and therapeutic methods of use therefore in promoting hydration of mucosal surfaces and the treatment of diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis, acute and chronic bronchitis, cystic fibrosis, emphysema, and pneumonia.

  本发明涉及以下化合物的公式：或其药用可接受的盐，以及含有该化合物的组合物，制备该化合物的方法，以及用于促进粘膜表面水合和治疗慢性阻塞性肺疾病（COPD）、哮喘、支气管扩张、急慢性支气管炎、囊性纤维化、肺气肿和肺炎等疾病的治疗方法。
• DENDRIMER LIKE AMINO AMIDES POSSESSING SODIUM CHANNEL BLOCKER ACTIVITY FOR THE TREATMENT OF DRY EYE AND OTHER MUCOSAL DISEASES
  申请人：PARION SCIENCES, INC.

  公开号：US20150099764A1

  公开（公告）日：2015-04-09

  Sodium channel blockers represented by the formula: are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.

  提供了由以下公式表示的钠通道阻滞剂，其中结构变量在此定义。本发明还包括多种组合物、组合和治疗方法，使用这些创新的钠通道阻滞剂。