2-[3,6-Dihydroxy-9-methyl-4,5-bis[[methyl-[2-(methylamino)ethyl]amino]methyl]xanthen-9-yl]benzaldehyde

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-[3,6-Dihydroxy-9-methyl-4,5-bis[[methyl-[2-(methylamino)ethyl]amino]methyl]xanthen-9-yl]benzaldehyde
• 英文别名: 2-[3,6-dihydroxy-9-methyl-4,5-bis[[methyl-[2-(methylamino)ethyl]amino]methyl]xanthen-9-yl]benzaldehyde
• 化学式: C₃₁H₄₀N₄O₄
• 分子量: 532.7
• InChiKey: OALUKYSAEBUHPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  39
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  97.3
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• [EN] BACTERIA TARGETING NANOPARTICLES AND RELATED METHODS OF USE<br/>[FR] NANOPARTICULES DE CIBLAGE DE BACTÉRIES ET PROCÉDÉS D'UTILISATION APPARENTÉS
  申请人：UNIV MICHIGAN

  公开号：WO2014093031A1

  公开（公告）日：2014-06-19

  The present invention relates to bacteria-targeting nanoparticles and related methods of use. In particular, the present invention relates to dendrimer nanoparticles conjugated with Vancomycin and/or Polymixin (e.g., Polymixin B, Polymixin E). In certain embodiments, such dendrimer nanoparticles are used to sequester and/or identify bacteria (e.g., Gram-positive bacteria and/or Gram-negative bacteria), screen liquid samples (e.g., water samples, food samples, pharmaceutical samples, blood samples, blood platelet samples, etc.) for the presence of bacteria (e.g., Gram-positive bacteria and/or Gram-negative bacteria), treat disorders associated with bacteria (e.g., Gram-positive bacteria and/or Gram-negative bacteria), and/or identify, sequester, and remove bacteria (e.g., Gram-positive bacteria and/or Gram-negative bacteria) from a liquid sample (e.g., water sample, food sample, pharmaceutical sample, blood sample, blood platelet sample, etc.). In certain embodiments, iron oxide nanoparticles are coated with dendrimer nanoparticles conjugated with Vancomycin and/or Polymixin.