N-(2-hydroxyethyl)-4-methoxy-N-[2-[[methyl(naphthalen-2-ylmethyl)amino]methyl]phenyl]benzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(2-hydroxyethyl)-4-methoxy-N-[2-[[methyl(naphthalen-2-ylmethyl)amino]methyl]phenyl]benzenesulfonamide
• 化学式: C₂₈H₃₀N₂O₄S
• 分子量: 490.6
• InChiKey: HZNAOGHPVYJTHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  78.5
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF X-LINKED CHARCOT-MARIE-TOOTH
  申请人：INSERM - Institut National de la Santé et de la Recherche Médicale

  公开号：EP2931267A1

  公开（公告）日：2015-10-21
• Methods and Pharmaceutical Compositions for the Treatment of X-Linked Charcot-Marie-Tooth
  申请人：INSERM (Institut National de la Santé et de la Recherche Médicale)

  公开号：US20150329483A1

  公开（公告）日：2015-11-19

  The present invention relates to methods and pharmaceutical compositions for the treatment of X-linked Charcot-Marie-Tooth. In particular, the present invention relates to a method for the treatment of CMTX in a subject in need thereof comprising administering the subject with a therapeutically effective amount of an inhibitor of CamKII activity or expression.
• [EN] METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF X-LINKED CHARCOT-MARIE-TOOTH<br/>[FR] PROCÉDÉS ET COMPOSITIONS PHARMACEUTIQUES POUR LE TRAITEMENT DE LA MALADIE DE CHARCOT-MARIE-TOOTH LIÉE AU CHROMOSOME X
  申请人：INSERM INST NAT DE LA SANTÉ ET DE LA RECH MÉDICALE

  公开号：WO2014095757A1

  公开（公告）日：2014-06-26

  The present invention relates to methods and pharmaceutical compositions for the treatment of X-linked Charcot-Marie-Tooth. In particular, the present invention relates to a method for the treatment of CMTX in a subject in need thereof comprising administering the subject with a therapeutically effective amount of an inhibitor of CamKII activity or expression.