dimethyl 1-[2-[(4S)-4-hydroxy-3,4-dihydro-2H-quinolin-1-yl]pyridin-4-yl]-6,7-dimethoxynaphthalene-2,3-dicarboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: dimethyl 1-[2-[(4S)-4-hydroxy-3,4-dihydro-2H-quinolin-1-yl]pyridin-4-yl]-6,7-dimethoxynaphthalene-2,3-dicarboxylate
• 化学式: C₃₀H₂₈N₂O₇
• 分子量: 528.6
• InChiKey: SWCQLKNFUNSPLC-QHCPKHFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  39
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  107
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• METHOD FOR PRODUCING OPTICALLY ACTIVE NAPHTHALENE COMPOUND
  申请人：Matsuyama Koji

  公开号：US20150152082A1

  公开（公告）日：2015-06-04

  The present invention provides an industrially advantageous method for producing an optically active naphthalene compound useful as a therapeutic agent for dermatitis or the like. Specifically, the present invention provides a method for producing an optically active naphthalene compound [I], which comprises: a step of reacting a compound [a-1] and a compound [b-1] with each other in the presence of a base and a catalyst that is composed of a Pd compound and a tertiary phosphine ligand (step a); a step of asymmetrically hydrogenating a compound [c-1] in the presence of a hydrogen donor and a complex that is prepared from a ruthenium compound and a chiral ligand, or alternatively in the presence of an optically active oxazaborolidine compound (a CBS catalyst) and a boron hydride compound (step b); and a step of treating a compound [d-1] with a reducing agent (step c). (In the above formulae, R a and R b represent the same or different lower alkyl groups; and X 1 represents a halogen atom.)

  本发明提供了一种在工业上具有优势的方法，用于生产一种光学活性萘化合物，该化合物可用作治疗皮炎或类似疾病的治疗剂。具体而言，本发明提供了一种生产光学活性萘化合物[I]的方法，包括以下步骤：在碱和由Pd化合物和三级膦配体组成的催化剂存在下，将化合物[a-1]和化合物[b-1]彼此反应（步骤a）；在氢供体和由钌化合物和手性配体制备的配合物或者在光学活性氧杂硼烷化合物（CBS催化剂）和硼氢化合物存在下，对化合物[c-1]进行不对称氢化（步骤b）；以及用还原剂处理化合物[d-1]（步骤c）。 （在上述公式中，Ra和Rb表示相同或不同的低碳基团；X1表示卤素原子。）
• Method for producing optically active naphthalene compound
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP2868659B1

  公开（公告）日：2016-05-04
• US9181217B2
  申请人：——

  公开号：US9181217B2

  公开（公告）日：2015-11-10