(NE)-N-[(E)-1-[8,8-dimethyl-5-(4-methylphenyl)-7H-naphthalen-2-yl]-3-(4-methylphenyl)prop-2-enylidene]hydroxylamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (NE)-N-[(E)-1-[8,8-dimethyl-5-(4-methylphenyl)-7H-naphthalen-2-yl]-3-(4-methylphenyl)prop-2-enylidene]hydroxylamine
• 化学式: C₂₉H₂₉NO
• 分子量: 407.5
• InChiKey: RRWFIJPMNVTTBX-HNJQTWEMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  32.6
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Treatment of Graft-Versus-Host Disease Disorders using RAR Antagonists
  申请人：Io Therapeutics, Inc.

  公开号：US20140194517A1

  公开（公告）日：2014-07-10

  The present specification provides RAR antagonist compounds, compositions comprising such RAR antagonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RAR antagonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection.