(5E)-3-ethyl-5-[(2Z)-2-(3-ethyl-4,5-diphenyl-1,3-thiazol-2(3H)-ylidene)ethylidene]-2-thioxo-1,3-thiazolidin-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (5E)-3-ethyl-5-[(2Z)-2-(3-ethyl-4,5-diphenyl-1,3-thiazol-2(3H)-ylidene)ethylidene]-2-thioxo-1,3-thiazolidin-4-one
• 英文别名: (5E)-3-ethyl-5-[(2Z)-2-(3-ethyl-4,5-diphenyl-1,3-thiazol-2-ylidene)ethylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
• 化学式: C₂₄H₂₂N₂OS₃
• 分子量: 450.6
• InChiKey: AAYUBURRNWYFKI-IBPVTIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  106
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• ANTI-NEURODEGENERATIVE DISEASE AGENT
  申请人：Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo

  公开号：EP2397139A1

  公开（公告）日：2011-12-21

  The present invention has an object to provide a novel agent for anti-neurodegenerative diseases and solves the object by providing an agent for anti-neurodegenerative diseases containing, as an effective ingredient, the compound(s) represented by the following General formula 1: wherein in General formula 1, R1 through R3 independently represent a hydrogen atom or an appropriate substituent; Z1 represents a heterocyclic ring and Z2 represents the same or different heterocyclic or aromatic ring as in Z1, wherein the heterocyclic and aromatic rings optionally have a substituent; o represents an integer of 0, 1 or 2; p represents an integer of 0 or 1, with the proviso that p is 1 when o is 0 or 2, and p is 0 when o is 1; R1 and R2 do not exist when o is 0, while, when p is 0, R3 does not exist and the binding between the carbon atom to which R2 binds and Z2 is a single bond; X1- represents an appropriate counter anion and q represents an integer of 1 or 2.

  本发明的目的是提供一种抗神经退行性疾病的新型制剂，并通过提供一种抗神经退行性疾病的制剂来解决该目的，该制剂含有以下通式 1 所代表的化合物作为有效成分： 其中在通式 1 中，R1 至 R3 独立地代表氢原子或适当的取代基；Z1 代表杂环，Z2 代表与 Z1 相同或不同的杂环或芳香环，其中杂环和芳香环可选择具有取代基；o 代表 0、1 或 2 的整数；当 o 为 0 时，R1 和 R2 不存在，而当 p 为 0 时，R3 不存在，R2 所结合的碳原子与 Z2 之间的结合为单键；X1- 代表适当的反阴离子，q 代表 1 或 2 的整数。