1-Butoxycarbonylindazole-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 1-Butoxycarbonylindazole-3-carboxylic acid
• 英文别名: 1-butoxycarbonylindazole-3-carboxylic acid
• 化学式: C₁₃H₁₄N₂O₄
• 分子量: 262.26
• InChiKey: CPOMNWIXOIFRJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  81.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP2945943A2

  公开（公告）日：2015-11-25
• [EN] PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS<br/>[FR] PHTALAZINONES ET ISOQUINOLINONES EN TANT QU'INHIBITEURS DE ROCK
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2014113620A2

  公开（公告）日：2014-07-24

  The present invention provides compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
• [EN] CONJUGATES OF π-ELECTRON-PAIR-DONATING HETEROAROMATIC NITROGEN-COMPRISING COMPOUNDS<br/>[FR] CONJUGUÉS DE COMPOSÉS AZOTÉS HÉTÉROAROMATIQUES DONNEURS DE PAIRES D'ÉLECTRONS π
  申请人：ASCENDIS PHARMA AS

  公开号：WO2020254603A1

  公开（公告）日：2020-12-24

  The present invention relates to conjugates of π-electron-pair-donating heteroaromatic nitrogen-comprising drugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising said conjugates and the use of said conjugates as medicaments.