(9S)-7-[(2S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-(hydroxymethyl)-8,10-dihydro-7H-tetracene-5,12-dione

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 蒽环类药物
• 英文名称: (9S)-7-[(2S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-(hydroxymethyl)-8,10-dihydro-7H-tetracene-5,12-dione
• 化学式: C₂₇H₂₉NO₁₁
• 分子量: 543.5
• InChiKey: QRQVSBBRBLJRCR-OAXWDPKZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  39
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  217
• 氢给体数：
  7
• 氢受体数：
  12

文献信息

• Metal-salen complex compound, local anesthetic and antineoplastic drug
  申请人：IHI Corporation

  公开号：US10034851B2

  公开（公告）日：2018-07-31

  A metal-salen complex compound, which exhibits excellent noninvasiveness and can be efficiently transferred to an affected site, a local anesthetic containing this metal-salen complex compound, and an antineoplastic drug containing this metal-salen complex compound are provided. Regarding the metal-salen complex compound, a metal atom part in each of two molecules of a metal-salen complex or a derivative of the metal-salen complex is dimerized via water, and the metal-salen complex compound is mixed with a base to produce an ointment.

  本发明提供了一种金属-莎伦络合物、一种含有该金属-莎伦络合物的局部麻醉剂和一种含有该金属-莎伦络合物的抗肿瘤药物，该金属-莎伦络合物具有极佳的非侵入性，可以有效地转移到患处。关于金属-盐氨酸络合物，金属-盐氨酸络合物或金属-盐氨酸络合物衍生物的两个分子中的每个分子中的一个金属原子部分通过水进行二聚，然后将金属-盐氨酸络合物与碱混合制成软膏。
• METAL-SALEN COMPLEX COMPOUND, LOCAL ANESTHETIC AND ANTINEOPLASTIC DRUG
  申请人：Ishikawa Yoshihiro

  公开号：US20140206635A1

  公开（公告）日：2014-07-24

  A metal-salen complex compound, which exhibits excellent noninvasiveness and can be efficiently transferred to an affected site, a local anesthetic containing this metal-salen complex compound, and an antineoplastic drug containing this metal-salen complex compound are provided. Regarding the metal-salen complex compound, a metal atom part in each of two molecules of a metal-salen complex or a derivative of the metal-salen complex is dimerized via water, and the metal-salen complex compound is mixed with a base to produce an ointment.