2-(Thietan-2-yl)oxetane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环丁烷
• 英文名称: 2-(Thietan-2-yl)oxetane
• 英文别名: 2-(thietan-2-yl)oxetane
• 化学式: C₆H₁₀OS
• 分子量: 130.21
• InChiKey: CRLADASFPRSRJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  34.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] BETA-LACTAMASE INHIBITORS<br/>[FR] INHIBITEURS DE BÊTA-LACTAMASE
  申请人：VENATORX PHARMACEUTICALS INC

  公开号：WO2014151958A1

  公开（公告）日：2014-09-25

  Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

  本文描述了一些能够调节β-内酰胺酶活性的化合物和组合物。在某些实施例中，所述化合物能够抑制β-内酰胺酶。在特定实施例中，所述化合物在治疗细菌感染方面具有用处。
• [EN] PYRAZOLINE DERIVATIVES AS INSECTICIDAL COMPOUNDS<br/>[FR] DÉRIVÉS DE PYRAZOLINE EN TANT QUE COMPOSÉS INSECTICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2014114250A1

  公开（公告）日：2014-07-31

  The present invention relates to compounds of formula (I) wherein P is selected from P1 and P2, or P and R5 together are P3 or P is a heterocycle H, selected from H1 to H9 wherein Y1, Y2 and Y3 are independently of each other C-H, C-R5, or nitrogen; and G1, G2, G3,Z, R1, R2, R3, R4, R5, R6a, R6b, R7, R8, R9, R10, R11, p, n and k are as defined in the claims. The invention also relates to methods of controlling insects, acarines, nematodes or molluscs which comprises applying to a pest, to a locus of a pest, or to a plant susceptible to attack by a pest an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound of formula (I).

  本发明涉及式(I)的化合物，其中P从P1和P2中选择，或P和R5一起是P3，或P是从H1到H9中选择的杂环H，其中Y1，Y2和Y3独立地是C-H，C-R5或氮; G1，G2，G3，Z，R1，R2，R3，R4，R5，R6a，R6b，R7，R8，R9，R10，R11，p，n和k如权利要求所定义。本发明还涉及控制昆虫、螨虫、线虫或软体动物的方法，包括向害虫、害虫的场所或易受攻击的植物施用式(I)的化合物的杀虫、杀螨、杀线虫或杀软体动物的有效量。
• BETA-LACTAMASE INHIBITORS
  申请人：VENATORX PHARMACEUTICALS, INC.

  公开号：US20160024121A1

  公开（公告）日：2016-01-28

  Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

  本文介绍了一些调节β-内酰胺酶活性的化合物和组合物。在某些实施例中，所述化合物抑制β-内酰胺酶。在某些实施例中，所述化合物可用于治疗细菌感染。
• ORALLY BIOAVAILABLE BETA-LACTAMASE INHIBITORS
  申请人：VenatoRX Pharmaceuticals, Inc.

  公开号：US20150361108A1

  公开（公告）日：2015-12-17

  Described herein are compounds and compositions that modulate the activity of beta-lactamases and methods thereof. In some embodiments, the compounds described herein are biologically hydrolyzed to a beta-lactamase inhibitor. In certain embodiments, the compounds described herein are useful for the treatment of bacterial infections.

  本文描述了调节β-内酰胺酶活性的化合物和组合物及其方法。在某些实施例中，本文所描述的化合物在生物体内水解成β-内酰胺酶抑制剂。在某些实施例中，本文所描述的化合物可用于治疗细菌感染。
• Beta-lactamase inhibitors
  申请人：VenatoRx Pharmaceuticals, Inc.

  公开号：US10294248B2

  公开（公告）日：2019-05-21

  Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

  本文描述了调节β-内酰胺酶活性的化合物和组合物。在某些实施方案中，本文所述化合物可抑制β-内酰胺酶。在某些实施方案中，本文所述化合物可用于治疗细菌感染。