2-Chloro-3-(3-hydroxy-4-methylanilino)naphthalene-1,4-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-Chloro-3-(3-hydroxy-4-methylanilino)naphthalene-1,4-dione
• 英文别名: 2-chloro-3-(3-hydroxy-4-methylanilino)naphthalene-1,4-dione
• 化学式: C₁₇H₁₂ClNO₃
• 分子量: 313.7
• InChiKey: FTINDJZFIROHKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• NAPHTHOQUINONE DERIVATIVES USEFUL FOR PREVENTION OF AMYLOID DEPOSITS AND TREATMENT OF DISEASES INVOLVING AMYLOIDOGENESIS
  申请人：RAMOT AT TEL AVIV UNIVERSITY LTD.

  公开号：US20140213627A1

  公开（公告）日：2014-07-31

  The present invention provides pharmaceutical compositions comprising substituted 1,4 naphthoquinones that are effective in preventing oligomerization of beta amyloid and subsequent pathologies associated with amyloid fibrils. These compositions are useful for the treatment of disease involving amyloidogenesis including neurodegenerative diseases such as Alzheimer's Disease or senile dementia. Particularly effective compositions comprise 1,4 naphthoquinones substituted with an amino acid residue selected from a heterocyclic or aromatic amino acid.
• US9272993B2
  申请人：——

  公开号：US9272993B2

  公开（公告）日：2016-03-01