2-(3-Hydroxy-6-oxoxanthen-9-yl)-5-[3-(2-methylpropanoylamino)propylcarbamothioylamino]benzoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-(3-Hydroxy-6-oxoxanthen-9-yl)-5-[3-(2-methylpropanoylamino)propylcarbamothioylamino]benzoic acid
• 英文别名: 2-(3-hydroxy-6-oxoxanthen-9-yl)-5-[3-(2-methylpropanoylamino)propylcarbamothioylamino]benzoic acid
• 化学式: C₂₈H₂₇N₃O₆S
• 分子量: 533.6
• InChiKey: DBOCWWSFLJRVQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  169
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• CONJUGATE OF A POLYMER, AN ANTI-ANGIOGENESIS AGENT AND A TARGETING MOIETY, AND USES THEREOF IN THE TREATMENT OF BONE RELATED ANGIOGENESIS CONDITIONS
  申请人：University of Utah Research Foundation

  公开号：US20140212357A1

  公开（公告）日：2014-07-31

  Conjugates of hydroxypropyl methacrylamide (HPMA)-derived copolymers having attached thereto TNP-470 and a high load (e.g., higher than 3 mol %) of alendronate (ALN), and processes of preparing same are disclosed. Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and an oligoaspartate bone targeting agent, and processes of preparing same, are further disclosed. Pharmaceutical compositions containing these conjugates and uses thereof in the treatment and monitoring of bone related disorders are also disclosed.