3-tert-butyl-5-propan-2-yl-4H-pyrazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环化合物
• 英文名称: 3-tert-butyl-5-propan-2-yl-4H-pyrazole
• 化学式: C₁₀H₁₈N₂
• 分子量: 166.26
• InChiKey: NWOXKMWVXIAXFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  24.7
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS
  申请人：INTERMUNE, INC.

  公开号：US20140200215A1

  公开（公告）日：2014-07-17

  Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the lysophosphatidic acid receptors are provided.

  提供的是化合物、制造这些化合物的方法、包含这些化合物的药物组合物和药品，以及使用这些化合物来治疗、预防或诊断与一个或多个溶血磷脂酸受体相关的疾病、失调或状况的方法。
• HISTONE DEACETYLASE (HDAC) INHIBITORS TARGETING PROSTATE TUMORS AND METHODS OF MAKING AND USING THEREOF
  申请人：Oyelere Adegboyega

  公开号：US20130289085A1

  公开（公告）日：2013-10-31

  Compounds of Formula (I), and methods of making and using thereof, are described herein; wherein AR is an aryl group, ZBG is a Zinc Binding Group, and other substituents are as defined herein. The compounds can be administered as a pharmaceutically acceptable salt, prodrug, or solvate. The compounds may be useful to treat and/or prevent hyperproliferative disorders which may include hormone sensitive and hormone refractory prostate cancers. The compounds can be formulated with a pharmaceutically acceptable carrier and, optionally one or more pharmaceutically acceptable excipients, for enteral or parenteral administration.

  本文介绍了化学式（I）的化合物及其制备和使用方法；其中AR是芳基基团，ZBG是锌结合基团，其他取代基的定义如本文所述。这些化合物可以作为药物可接受的盐、前药或溶剂形式进行给药。这些化合物可能有助于治疗和/或预防过度增殖性疾病，包括激素敏感和激素耐药的前列腺癌。这些化合物可以与药物可接受的载体和可选的一个或多个药物可接受的辅料一起制成口服或静脉给药制剂。
• PYRIDAZINE DERIVATIVES AS RORc MODULATORS
  申请人：Genentech, Inc.

  公开号：US20180222882A1

  公开（公告）日：2018-08-09

  Compounds of formula I: or pharmaceutical salts thereof, wherein m, n, A, R1, R 2 , R 3 , R 4 and R 5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
• US9139565B2
  申请人：——

  公开号：US9139565B2

  公开（公告）日：2015-09-22
• US9156818B2
  申请人：——

  公开号：US9156818B2

  公开（公告）日：2015-10-13