(2-Oxo-2-thiophen-2-ylethyl) 5-nitrofuran-2-carboxylate | 379731-20-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: (2-Oxo-2-thiophen-2-ylethyl) 5-nitrofuran-2-carboxylate
• CAS: 379731-20-1
• 化学式: C11H7NO6S
• 分子量: 281.24
• InChiKey: IQQSGGUFESWJGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  131
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• ANTIBIOTIC COMPOUNDS AND COMPOSITIONS, AND METHODS FOR IDENTIFICATION THEREOF
  申请人：Fred Hutchinson Cancer Research Center

  公开号：US20150126519A1

  公开（公告）日：2015-05-07

  Disclosed herein are compounds and methods for inhibiting bacterial DNA repair enzymes, including AddAB and RecBCD helicase-nucleases. Pharmaceutical compositions and methods for treating a subject with an antibacterial agent are also disclosed herein.
• [EN] ANTIBIOTIC COMPOUNDS AND COMPOSITIONS, AND METHODS FOR IDENTIFICATION THEREOF<br/>[FR] COMPOSÉS ET COMPOSITIONS ANTIBIOTIQUES, ET PROCÉDÉS D'IDENTIFICATION ASSOCIÉS
  申请人：HUTCHINSON FRED CANCER RES

  公开号：WO2013142628A2

  公开（公告）日：2013-09-26

  Disclosed herein are compounds and methods for inhibiting bacterial DNA repair enzymes, including AddAB and RecBCD helicase-nucleases. Pharmaceutical compositions and methods for treating a subject with an antibacterial agent are also disclosed herein.