2-[(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-yl)carbamoyl]butanethioic S-acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-[(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-yl)carbamoyl]butanethioic S-acid
• 化学式: C₂₅H₁₉NO₇S
• 分子量: 477.5
• InChiKey: TZSSPBSUHXRVIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  123
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• COMPOSITIONS AND METHODS FOR TARGETED TUMOR IMMUNOTHERAPY
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US20200306376A1

  公开（公告）日：2020-10-01

  The present invention provides universal immunotherapy compositions useful for targeted treatment of cancers. The present invention utilizes in its various aspects, bifunctional compounds or complexes that contain at least two domains. One domain, referred to herein as a targeting moiety, binds an antigen on the surface of a tumor cell. The other domain, referred to herein as a pro-antigen, is designed to be inert to normal (non-diseased) cells and tissues, and to become activated (or “unmasked” or “unaged”) only upon exposure to light of an appropriate wavelength.
• TARGETING OF MULTIPLE ANTIGENS WITH MULTIPLEX CAR T CELLS IN SOLID AND LIQUID MALIGNANCIES
  申请人：DANA-FARBER CANCER INSTITUTE, INC.

  公开号：US20210137987A1

  公开（公告）日：2021-05-13

  Disclosed are compositions and methods for treating cancers characterized by the presence of solid tumors, which simultaneously target a plurality of targets on cancer cells using single CAR T construct.
• COMPOSITIONS AND METHODS FOR TARGETED IMMUNOTHERAPY
  申请人：DANA-FARBER CANCER INSTITUTE, INC.

  公开号：US20210228699A1

  公开（公告）日：2021-07-29

  The present invention provides universal immunotherapy compositions useful for targeted treatment of cancers.
• [EN] PHOTOCATALYTIC DEGRADATION OF SUGAR<br/>[FR] DÉCOMPOSITION PHOTOCATALYTIQUE D'UN SUCRE
  申请人：EMPIRE TECHNOLOGY DEV LLC

  公开号：WO2014126647A1

  公开（公告）日：2014-08-21

  Systems having at least one photonic antenna molecule and at least one catalyst for degrading a sugar to degradation products using light energy are disclosed. Also disclosed are the devices and methods that use the systems for photocatalytically degrading a sugar into degradation products.
• [EN] METHODS FOR OPTICAL MAPPING OF POLYNUCLEOTIDES<br/>[FR] PROCÉDÉS DE CARTOGRAPHIE OPTIQUE DE POLYNUCLÉOTIDES
  申请人：UNIV DANMARKS TEKNISKE

  公开号：WO2017220637A1

  公开（公告）日：2017-12-28

  The present invention relates to methods for the optical mapping and subsequent analysis, such as sequencing of polynucleotides, such as genomic DNA, in microchannel devices.