2-Hydroxy-3-phenylpropanoic acid;propan-2-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 2-Hydroxy-3-phenylpropanoic acid;propan-2-one
• 英文别名: 2-hydroxy-3-phenylpropanoic acid;propan-2-one
• 化学式: C12H16O4
• 分子量: 224.25
• InChiKey: CAXLVZDLPWOGDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.27
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• CABAZITAXEL AND ITS USE FOR TREATING METASTATIC PROSTATE CANCERS
  申请人：Aventis Pharma S.A.

  公开号：EP2964212A1

  公开（公告）日：2016-01-13
• [EN] CABAZITAXEL AND ITS USE FOR TREATING METASTATIC PROSTATE CANCERS<br/>[FR] CABAZITAXEL ET SON UTILISATION POUR LE TRAITEMENT DES CANCERS DE LA PROSTATE MÉTASTATIQUES
  申请人：AVENTIS PHARMA SA

  公开号：WO2014135524A1

  公开（公告）日：2014-09-12

  The present invention relates to the compound having the following formula: (I), which may be in base form or in the form of a hydrate or a solvate, in combination with prednisone or prednisolone, for its use for the treatment of castration resistant or hormone-refractory metastatic prostate cancer in patients not at risk of developing gastrointestinal disorders chosen from the group consisting of: gastrointestinal bleeding and perforation, gastritis, enterocolitis, neutropenic enterocolitis, colitis, intestinal obstruction, and ileus.