(E)-but-2-enedioic acid;3,6-dimethyl-1,4-dioxane-2,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: (E)-but-2-enedioic acid;3,6-dimethyl-1,4-dioxane-2,5-dione
• 化学式: C10H12O8
• 分子量: 260.2
• InChiKey: VGAZOGWAYCLURB-WLHGVMLRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.42
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  127
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Nanocapsule containing a bioactive compound, and a method of reducing toxicity resulting from cancer therapy
  申请人：King Abdulaziz University

  公开号：US10251842B1

  公开（公告）日：2019-04-09

  Nanocapsules of bioactive compounds derived from natural products as an adjunct treatment for cancer. Nanocapsules of bioactive compounds showed synergy in the treatment of cancer therapy-induced toxicity.

  从天然产品中提取的生物活性化合物纳米胶囊可作为癌症的辅助疗法。生物活性化合物纳米胶囊在治疗癌症治疗引起的毒性方面显示出协同作用。
• FUNCTIONALIZED PRUSSIAN BLUE NANOPARTICES, COMBINATION PRUSSIAN BLUE NANOPARTICLE-BASED NANO-IMMUNOTHERAPHY AND APPLICATIONS THEREOF
  申请人：CHILDREN'S NATIONAL MEDICAL CENTER

  公开号：EP3426300A1

  公开（公告）日：2019-01-16
• US20140271487A1
  申请人：——

  公开号：US20140271487A1

  公开（公告）日：2014-09-18
• PRUSSIAN BLUE-INSPIRED CONSTRUCTS FOR MULTIMODAL IMAGING AND THERAPY
  申请人：Children's National Medical Center

  公开号：US20170173187A1

  公开（公告）日：2017-06-22

  The invention describes a coordination polymer construct for multimodal imaging and therapy. The construct consists of a core particle made of a novel coordination polymer. The core is coated with a biocompatible coating that stabilizes the particles in a physiological environment. The biocompatible coating can contain attached targeting agents, imaging agents and therapeutic agents or combinations one or more of the targeting, imaging and therapeutic agents. When administered to a subject or a subject-derived specimen, the resulting coordination polymer core-shell construct enables multimodal imaging and therapy, which improves the diagnostic and treatment outcomes of the conditions or diseases where it is administered. The invention describes the novel material, base for the construct, methods for the preparation of the said construct and its use as a multimodal imaging and therapy agent.
• NANOCAPSULE CONTAINING A BIOACTIVE COMPOUND, AND A METHOD OF REDUCING TOXICITY RESULTING FROM CANCER THERAPY
  申请人：King Abdulaziz University

  公开号：US20190125684A1

  公开（公告）日：2019-05-02

  Nanocapsules of bioactive compounds derived from natural products as an adjunct treatment for cancer. Nanocapsules of bioactive compounds showed synergy in the treatment of cancer therapy-induced toxicity.