1-[[(2R,3S)-8-[2-(4-fluorophenyl)ethynyl]-5-(1-hydroxypropan-2-yl)-3-methyl-6-oxo-3,4-dihydro-2H-pyrido[2,3-b][1,5]oxazocin-2-yl]methyl]-1-methyl-3-naphthalen-1-ylurea

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-[[(2R,3S)-8-[2-(4-fluorophenyl)ethynyl]-5-(1-hydroxypropan-2-yl)-3-methyl-6-oxo-3,4-dihydro-2H-pyrido[2,3-b][1,5]oxazocin-2-yl]methyl]-1-methyl-3-naphthalen-1-ylurea
• 化学式: C₃₄H₃₃FN₄O₄
• 分子量: 580.6
• InChiKey: XTRVXRQVAGSVFF-QPVYAYPCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  43
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  95
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• COMPOUNDS FOR INDUCING PROLIFERATION AND DIFFERENTIATION OF CELLS, AND METHODS OF USE THEREOF
  申请人：THE BROAD INSTITUTE, INC.

  公开号：US20160031837A1

  公开（公告）日：2016-02-04

  The present invention provides methods of inducing proliferation of and/or differentiating cells comprising contacting cells with compounds within the methods of the invention. The present invention further provides cells obtainable by the methods of the invention. Liver disease affects more than 500 million people worldwide. Organ transplantation is the gold standard for treatment of liver failure, but organ shortages are acute.

  本发明提供了诱导细胞增殖和/或分化的方法，包括将细胞与本发明方法中的化合物接触。本发明还提供了通过本发明方法获得的细胞。肝病影响全球超过5亿人。器官移植是治疗肝衰竭的金标准，但器官短缺严重。
• Compounds for inducing proliferation and differentiation of cells, and methods of use thereof
  申请人：The Broad Institute, Inc.

  公开号：US10081609B2

  公开（公告）日：2018-09-25

  The present invention provides methods of inducing proliferation of and/or differentiating cells comprising contacting cells with compounds within the methods of the invention. The present invention further provides cells obtainable by the methods of the invention. Liver disease affects more than 500 million people worldwide. Organ transplantation is the gold standard for treatment of liver failure, but organ shortages are acute.

  本发明提供了诱导细胞增殖和/或分化的方法，包括使细胞与本发明方法中的化合物接触。本发明进一步提供了可通过本发明方法获得的细胞。肝病影响着全球 5 亿多人。器官移植是治疗肝衰竭的黄金标准，但器官短缺问题十分严重。
• [EN] COMPOUNDS FOR INDUCING PROLIFERATION AND DIFFERENTIATION OF CELLS, AND METHODS OF USE THEREOF<br/>[FR] COMPOSÉS D'INDUCTION DE LA PROLIFÉRATION ET DE LA DIFFÉRENCIATION DE CELLULES ET PROCÉDÉS D'UTILISATION CORRESPONDANTS
  申请人：BROAD INST INC

  公开号：WO2014144125A1

  公开（公告）日：2014-09-18

  The present invention provides methods of inducing proliferation of and/or differentiating cells comprising contacting cells with compounds within the methods of the invention. The present invention further provides cells obtainable by the methods of the invention. Liver disease affects more than 500 million people worldwide. Organ transplantation is the gold standard for treatment of liver failure, but organ shortages are acute.