5-bromo-8-(2,3-dihydro-1H-benzimidazol-2-yl)naphthalene-1-carbaldehyde

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-bromo-8-(2,3-dihydro-1H-benzimidazol-2-yl)naphthalene-1-carbaldehyde
• 化学式: C₁₈H₁₃BrN₂O
• 分子量: 353.2
• InChiKey: XMDXBSXKDDXEQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• TWO-PHOTON FLUORESCENT PROBE USING NAPHTHALENE AS MATRIX AND PREPARATION METHOD AND USE THEREOF
  申请人：Dalian Chromas Bioscience Co., Ltd.

  公开号：EP2778161A1

  公开（公告）日：2014-09-17

  The present invention provides a novel category of naphthalene-based two-photon fluorescent probes having a general formula I, wherein: X is selected from the X1, X2, X3 and X4; The mentioned two-photon fluorescent probes have a low fluorescence background in the non-tumor cells and tissues, and have a strong and specific fluorescent signal in the tumor cells and tissues. These probes have a certain level of water-solubility, while having good membrane permeability. In addition, they have a bigger effective two-photon absorption cross section. The compounds of the present invention also have a lower biotoxicity, phototoxicity and photobleaching. There is sufficient difference between the spectral range thereof and that of a biological sample.

  本发明提供了一类新型的萘基双光子荧光探针，其通式为I，其中：所述双光子荧光探针在非肿瘤细胞和组织中具有较低的荧光背景，在肿瘤细胞和组织中具有较强的特异性荧光信号。这些探针具有一定的水溶性，同时具有良好的膜渗透性。此外，它们还具有较大的有效双光子吸收截面。本发明的化合物还具有较低的生物毒性、光毒性和光漂白性。本发明化合物的光谱范围与生物样本的光谱范围有足够的差异。