12-(2-Oxopropyl)-10,12-diazatricyclo[7.4.1.05,14]tetradeca-1,3,5(14),6,8-pentaen-11-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 12-(2-Oxopropyl)-10,12-diazatricyclo[7.4.1.05,14]tetradeca-1,3,5(14),6,8-pentaen-11-one
• 英文别名: 12-(2-oxopropyl)-10,12-diazatricyclo[7.4.1.05,14]tetradeca-1,3,5(14),6,8-pentaen-11-one
• 化学式: C₁₅H₁₄N₂O₂
• 分子量: 254.28
• InChiKey: QFYQATJNGUSSNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• NOVEL METHODS, COMPOUNDS, AND COMPOSITIONS FOR INHIBITION OF ROS
  申请人：GRUENEBERG Dorre A.

  公开号：US20160031890A1

  公开（公告）日：2016-02-04

  The present invention relates to a method using some novel compounds and compositions for the inhibition of ROS tyrosine kinase. In particular, the present invention covers a method to treat abnormal cell growth, such as cancer, with ROS 10 inhibitors and compositions having ROS inhibitors. An illustrative compound of the invention is shown below Formula (I).
• US9963452B2
  申请人：——

  公开号：US9963452B2

  公开（公告）日：2018-05-08