4-Pentylsulfonylnaphthalen-1-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-Pentylsulfonylnaphthalen-1-amine
• 英文别名: 4-pentylsulfonylnaphthalen-1-amine
• 化学式: C₁₅H₁₉NO₂S
• 分子量: 277.4
• InChiKey: SLSSVOZSGRKVOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  68.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] FLUORESCENT RED-EMISSIVE COMPOUNDS FOR CELLULAR ORGANELLE IMAGING<br/>[FR] COMPOSÉS FLUORESCENTS ÉMISSIFS DANS LE ROUGE POUR IMAGERIE D'ORGANITES CELLULAIRES
  申请人：UNIV HONG KONG SCI & TECH

  公开号：WO2020253756A1

  公开（公告）日：2020-12-24

  Small molecule fluorescent compounds having aggregation-induced emission (AIE) characteristics are disclosed. The compounds exhibit red to near-infrared solid-state emission, large Stokes shift, high fluorescence quantum yield and good two-photon absorption cross section. The compounds can provide specific organelle staining in live cells and deep tissues. The compounds also exhibit high biocompatibility and high photostability under one-photon and two-photon continuous irradiation.

  揭示了具有聚集诱导发光（AIE）特性的小分子荧光化合物。这些化合物表现出红至近红固态发射、大的斯托克斯位移、高荧光量子产率和良好的双光子吸收截面。这些化合物可以在活细胞和深层组织中提供特定细胞器染色。这些化合物在单光子和双光子连续照射下也表现出高生物相容性和高光稳定性。
• [EN] SUBSTITUTED FLUORANTHENE-7-CARBONITRILES AS FLUORESCENT DYES FOR CELL IMAGING APPLICATIONS<br/>[FR] FLUORANTHÈNE-7-CARBONITRILES SUBSTITUÉS UTILISÉS EN TANT QUE COLORANTS FLUORESCENTS POUR DES APPLICATIONS D'IMAGERIE CELLULAIRE
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2014147642A1

  公开（公告）日：2014-09-25

  The present invention relates to novel donor-acceptor fluoranthenes of the general formula I which can be used potentially in developing fluorescent probes, and a process of preparing said novel compounds. More particularly, the present invention relates to amine or alkoxy group as donor and nitrile group as an acceptor attached to the fluoranthene skeleton, processes for preparing the said compounds and their uses as fluorescent probes in chemical and biological sciences such as cell imaging applications, diagnostics, fluorescent tags and other useful applications. The compounds are prepared by reacting 2H-pyran-2-ones in isolated or rigid conformations with cyclic ketones containing methylene carbonyl moiety in the presence of a base in an organic solvent.

  本发明涉及一种新型供体-受体氟蒽化合物，其通式为I，可能用于开发荧光探针，并提供了制备这些新型化合物的方法。更具体地说，本发明涉及将胺或烷氧基作为供体，将腈基作为受体连接到氟蒽骨架上，制备这些化合物的方法，以及它们在化学和生物科学中作为荧光探针的用途，如细胞成像应用、诊断、荧光标记和其他有用的应用。这些化合物是通过在有机溶剂中在孤立或刚性构象下，将2H-吡喃-2-酮与含有亚甲基羰基团的环状酮在碱存在下反应而制备的。
• Methods for increasing oil content in plant tissues by suppressing hydrophobic lipid droplet protein
  申请人：University of North Texas

  公开号：US10308950B2

  公开（公告）日：2019-06-04

  The present disclosure relates to increasing oil content in plants through manipulating expression of proteins, namely At5g16550 proteins. At5g16550 proteins are lipid droplet proteins. Plants having reduced expression of At5g16550 proteins demonstrate cytoplasmic lipid droplets (LDs) that are increased in size, resulting in greater overall oil content in the plant cells.

  本公开涉及通过操纵蛋白质（即 At5g16550 蛋白）的表达来提高植物的含油量。At5g16550 蛋白是脂滴蛋白。At5g16550 蛋白表达减少的植物表现出细胞质脂滴（LD）增大，从而提高了植物细胞中的整体含油量。
• Fat droplets in retina and optic nerve as a diagnostic marker for neurodegeneration and glaucoma in humans
  申请人：The Jackson Laboratory

  公开号：US11369695B2

  公开（公告）日：2022-06-28

  The present invention relates to the use of lipid/fat droplet deposits in retinas of a human subject as a biomarker for diagnosing, prognosing, and/or monitoring retinal neurodegeneration with or without an elevated intraocular pressure in glaucoma.

  本发明涉及将人类视网膜中的脂质/脂肪滴沉积物用作诊断、预后和/或监测青光眼眼压升高或不升高的视网膜神经变性的生物标志物。
• [EN] COMPOUND FOR PREVENTING OR TREATING LIPID METABOLISM-RELATED DISEASES<br/>[FR] COMPOSÉ POUR LA PRÉVENTION OU LE TRAITEMENT DE MALADIES LIÉES AU MÉTABOLISME LIPIDIQUE<br/>[ZH] 用于预防或治疗脂质代谢相关疾病的化合物
  申请人：UNIV FUDAN

  公开号：WO2021213518A1

  公开（公告）日：2021-10-28

  本发明涉及生物医药领域，并且具体地涉及将能够结合LC3的结构与能够结合脂滴的结构通过共价连接连接在一起，从而形成的"LC3结合部分-脂滴结合部分-偶联物"，其药学上可接受的盐、立体异构体、溶剂化物、多晶型、互变异构体、同位素化合物、代谢产物或前药，以及在制备用于预防或治疗脂质代谢相关疾病的药物中的用途。