2-[[5-(Cyclohexen-1-yl)-1-(oxan-2-yl)indazol-3-yl]methyl-methylamino]ethyl-methylcarbamic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 2-[[5-(Cyclohexen-1-yl)-1-(oxan-2-yl)indazol-3-yl]methyl-methylamino]ethyl-methylcarbamic acid
• 英文别名: 2-[[5-(cyclohexen-1-yl)-1-(oxan-2-yl)indazol-3-yl]methyl-methylamino]ethyl-methylcarbamic acid
• 化学式: C₂₄H₃₄N₄O₃
• 分子量: 426.6
• InChiKey: ISLWQTCLADYUNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  70.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF
  申请人：EPIZYME, INC.

  公开号：US20160024017A1

  公开（公告）日：2016-01-28

  Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.

  本文描述了公式（I）的化合物，其药学上可接受的盐以及其药物组合物。本发明的化合物可用于抑制精氨酸甲基转移酶活性。还描述了使用这些化合物治疗精氨酸甲基转移酶介导的疾病的方法。
• US9765035B2
  申请人：——

  公开号：US9765035B2

  公开（公告）日：2017-09-19
• [EN] ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE L'ARGININE MÉTHYLTRANSFÉRASE ET UTILISATIONS DE CEUX-CI
  申请人：EPIZYME INC

  公开号：WO2014153235A2

  公开（公告）日：2014-09-25

  Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.